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Overview

Uniprot ID	M0RBF8
Protein Name	Exocyst complex component Sec8
Gene Name	Exoc4
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
9	AAEAAGGKYRSTVSK

Function

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane

Protein Sequence

10 MAAEAAGGKY 20 RSTVSKSKDP 30 SGLLISVIRT 40 LSTSDDVEDR 50 ENEKGRLEEA 60 YEKCDRDLDE 70 LIVQHYTELT 80 TAIRTYQSIT 90 ERITNSRNKI 100 KQVKENLLSC 110 KMLLHCKRDE 120 LRKLWIEGIE 130 HKHVLNLLDE 140 IENIKQVPQK 150 LEQCMASKHY 160 LSATDMLVSA 170 VESLEGPLLQ 180 VEGLSDLRLE 190 LHSKKMNLHL 200 VLIEELHRHL 210 YIKSTSRVVQ 220 RNKEKGKMSS 230 HGKDASPGPL 240 IDVSNISTPR 250 KFLDATQYSA 260 AGSSSVREMN 270 LQDIKEDLDC 280 DPEENSTLFM 290 GILIQGLARL 300 KKIPETVKAI 310 KERLEQELKQ 320 IVKRSTTQVA 330 DSAYQRGESL 340 TVDNQPRLLL 350 ELLELLFDKF 360 NAVASAHSIV 370 LGYLQDSVGT 380 QPTQQEEIKL 390 YDMADVWVKI 400 QDVLQMLLTE 410 YLDMKNTRTA 420 SEPSAQLSYA 430 STGREFAAFF 440 AKKKPQRPKN 450 SLFKFESSSH 460 AISMSAYLRE 470 QRRELYSRSG 480 ELQGGPDDNL 490 IEGGGTKFVC 500 KPGARNITVI 510 FHPLLRFIQE 520 IEHALGLGPA 530 KQCPLREFLT 540 IYIKNIFLNQ 550 VLTEINKEIE 560 GVTKTSDPLK 570 ILANADTMKV 580 LGVQRPLLQS 590 TIIVEKTVQD 600 LMNLMHDLSA 610 YSDQFLNMVC 620 VKLQEYKDTC 630 STAYRGIVQS 640 EEKLVISASW 650 AKDDDISRLL 660 KSLPNWTNMA 670 QPKQLRPKRE 680 EEEDFIRAAF 690 GKESEVLIGN 700 LGDKLIPPQD 710 ILRDVSDLKA 720 LANMHESLEW 730 LAGRTKSAFS 740 SLSASQMLSP 750 AQESHVNMDL 760 PPVSEQIMQT 770 LSELAKSFQD 780 MADRCLLVLH 790 LEVRVHCFHY 800 LIPLAKEGNY 810 AIVANVESMD 820 YDPLVVKLNK 830 DISAMEEAMS 840 ASLQQHKFQY 850 IFEGLGHLIS 860 CILINGAQYF 870 RRISESGIKK 880 MCRNIFVLQQ 890 NLTNITMSRE 900 ADLDFARQYY 910 EMLYNTADEL 920 LNLVVDQGVK 930 YTELEYIHAL 940 TLLHRSQTGV 950 GDQTTQNTRL 960 QRLKEIICEQ 970 AAIKQATKDK KITTV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0000145	exocyst
Cellular Component	GO:0032584	growth cone membrane
Cellular Component	GO:0005902	microvillus
Cellular Component	GO:0035748	myelin sheath abaxonal region
Molecular Function	GO:0030742	GTP-dependent protein binding
Molecular Function	GO:0030165	PDZ domain binding
Biological Process	GO:0006612	protein targeting to membrane
Biological Process	GO:0015031	protein transport
Biological Process	GO:0006904	vesicle docking involved in exocytosis
Biological Process	GO:0090522	vesicle tethering involved in exocytosis

Reference

[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.