Search Results
Overview
| Uniprot ID | M0RCC8 |
|---|---|
| Protein Name | Mitochondrial peptide methionine sulfoxide reductase |
| Gene Name | Msra |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 132 | YTRNPTYKEVCSEKT |
| 211 | EYQKVLSKHGFGPIT |
Function
Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Plays a crucial role in repairing oxidized methionine residues in key lens proteins, such as alpha-crystallin (CRYAA/CRYAB) and cytochrome c (CYCS), thereby restoring their function and maintaining lens transparency
Protein Sequence
10
MLSASRRTLQ
20
LLSSSIPVRM
30
MGDSSSKVIS
40
AEEALPGRTE
50
SIPVAAALPT
60
PSLSPNQKLN
70
YFVWKEVPGK
80
HSWPEHHVSG
90
NRTVEPFPEG
100
TQMAVFGMGC
110
FWGAERKFWL
120
LKGVYSTQVG
130
FAGGYTRNPT
140
YKEVCSEKTG
150
HAEVVRVVYR
160
PEHVSFEELL
170
KVFWENHDPT
180
QGMRQGNDCG
190
TQYRSAVYPT
200
SAVQMEAALK
210
SKEEYQKVLS
220
KHGFGPITTD
230
IREGQVFYYA
240
EDYHQQYLSK
250
NPDGYCGLGG
260
TGVSCPTAIK
K
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.