Overview
| Uniprot ID | M0RD75 |
|---|
| Protein Name | 40S ribosomal protein S6 |
|---|
| Gene Name | Rps6 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 141 |
KRASRIRKLFNLSKE |
| 147 |
RKLFNLSKEDDVRQY |
| 201 |
KQRTKKNKEEAAEYA |
Function
Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome
Protein Sequence
10
LNISFPATGC
20
QKLIEVDDER
30
KLRTFYEKRM
40
ATEVAADALG
50
EEWKGYVVRI
60
SGGNDKQGFP
70
MKQGVLTHGR
80
VRLLLSKGHS
90
CYRPRRTGER
100
KRKSVRGCIV
110
DANLSVLNLV
120
IVKKGEKDIP
130
GLTDTTVPRR
140
LGPKRASRIR
150
KLFNLSKEDD
160
VRQYVVRKPL
170
NKEGKKPRTK
180
APKIQRLVTP
190
RVLQHKRRRI
200
ALKKQRTKKN
210
KEEAAEYAKL
220
LAKRMKEAKE
230
KRQEQIAKRR
240
RLSSLRASTS
KSESSQK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0044297 |
cell body |
| Cellular Component |
GO:0036464 |
cytoplasmic ribonucleoprotein granule |
| Cellular Component |
GO:0022627 |
cytosolic small ribosomal subunit |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0032040 |
small-subunit processome |
| Molecular Function |
GO:0019901 |
protein kinase binding |
| Molecular Function |
GO:0003735 |
structural constituent of ribosome |
| Biological Process |
GO:0002181 |
cytoplasmic translation |
| Biological Process |
GO:0043065 |
positive regulation of apoptotic process |
| Biological Process |
GO:0008284 |
positive regulation of cell population proliferation |
| Biological Process |
GO:0042274 |
ribosomal small subunit biogenesis |
| Biological Process |
GO:0006364 |
rRNA processing |
| Biological Process |
GO:0031929 |
TOR signaling |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.