Overview
| Uniprot ID | M3TYG7 |
|---|
| Protein Name | - |
|---|
| Gene Name | SERPINB1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 316 |
ARDLFISKVVHKSFV |
Function
Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also acts as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity. During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. When secreted, promotes the proliferation of beta-cells via its protease inhibitory function
Protein Sequence
10
MEQLSAANTR
20
FALDLFRALN
30
ESNPAGNIFI
40
SPFSISSALA
50
MILLGTRGNT
60
EAQMSKALHF
70
DTVKDIHSRF
80
QSLNADINKC
90
GASYILKLAN
100
RLFGEKTYHF
110
LPEFLASTQK
120
TYGAELASVD
130
FLRASEEARK
140
AINEWVKEQT
150
EGKIPELLAS
160
GVVDSATKLV
170
LVNAIYFKGS
180
WQEKFMTEAT
190
KDAPFRLNKK
200
DSKTVKMMYQ
210
KKKFPFGYIK
220
ELKCRVLELP
230
YQGKDLSMVI
240
LLPDSIEDES
250
TGLRKIEQHL
260
TLEKLREWTK
270
PDNLELLEVN
280
VHLPRFRLEE
290
SYDLNAPLAR
300
LGVQDLFGSR
310
ADLTGMSEAR
320
DLFISKVVHK
330
SFVEVNEEGT
340
EAAAATAGIA
350
VFAMLMPEED
360
FIADHPFIFF
370
IRHNPSSNIL
FLGRLSSP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005615 |
extracellular space |
| Molecular Function |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
| Biological Process |
GO:0032691 |
negative regulation of interleukin-1 beta production |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.