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Overview

Uniprot IDM3TYJ4
Protein NameDNA replication licensing factor MCM6
Gene NameMCM6
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
102 KTFVKDRKEIPLAKD
197 RFLLDTNKSRFVDFQ
205 SRFVDFQKVRIQETQ
407 TAKSQFLKHVEEFSP
422 RAVYTSGKASSAAGL
490 SITKAGVKATLNART
646 EVQPKHVKEAFRLLN
654 EAFRLLNKSIIRVET
775 NKKRIIEKVIYRLTH
95 PYLCRALKTFVKDRK

Function

Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity

Protein Sequence

10 MDLAAAAEPS 20 AGSQHLEVRD 30 EVAEKCQKLF 40 LDFLEEFQNS 50 DGEIKYLQLA 60 EELIRPERNT 70 LVVSFVDLEQ 80 FNQQLSTTIQ 90 EEFYRVYPYL 100 CRALKTFVKD 110 RKEIPLAKDF 120 YVAFQDLPTR 130 HKIRELNSSR 140 IGLLTRISGQ 150 VVRTHPVHPE 160 LVSGTFLCLD 170 CQTVIRDVEQ 180 QFKYTQPNIC 190 RNPVCANRKR 200 FLLDTNKSRF 210 VDFQKVRIQE 220 TQAELPRGSI 230 PRSLEVILRA 240 EAVESAQAGD 250 KCDFTGTLIV 260 VPDVSKLSTP 270 GARAETNSRV 280 NGVDGYETEG 290 IRGLRALGVR 300 DLSYRLVFLA 310 CCVAPTNPRF 320 GGKELRDEEQ 330 TAESIKNQMT 340 VKEWEKVFEM 350 SQDKNLYHNL 360 CTSLFPTIHG 370 NDEVKRGVLL 380 MLFGGVPKTT 390 GEGTSLRGDI 400 NVCIVGDPST 410 AKSQFLKHVE 420 EFSPRAVYTS 430 GKASSAAGLT 440 AAVVRDEESH 450 EFVIEAGALM 460 LADNGVCCID 470 EFDKMDVRDQ 480 VAIHEAMEQQ 490 TISITKAGVK 500 ATLNARTSIL 510 AAANPISGHY 520 DRSKSLKQNI 530 NLSAPIMSRF 540 DLFFILVDEC 550 NEVTDYAIAR 560 RIVDLHSRIE 570 DSIDRVYSLD 580 DIRRYLLFAR 590 QFKPKISKES 600 EDFIVEQYKR 610 LRQRDGSGVT 620 KSSWRITVRQ 630 LESMIRLSEA 640 MARMHCCDEV 650 QPKHVKEAFR 660 LLNKSIIRVE 670 TPDVNLDQEE 680 DAQMEVDESP 690 DGINGHADSP 700 APVNGINGHS 710 EDMNQDSVPK 720 ASLKLGFSEY 730 CRISNLIVLH 740 LRKMEEEEDE 750 SALKRSELVN 760 WYLKEIESEI 770 DSEEELINKK 780 RIIEKVIYRL 790 THYDHVLIEL 800 TQAGLKGSTE 810 GSESYEEDPY 820 LVVNPNYLLE D

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0042555 MCM complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0003678 DNA helicase activity
Molecular Function GO:0016787 hydrolase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0003697 single-stranded DNA binding
Biological Process GO:0006270 DNA replication initiation
Biological Process GO:0000727 double-strand break repair via break-induced replication
Biological Process GO:1902969 mitotic DNA replication

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.