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Overview

Uniprot ID	M3UZ25
Protein Name	Condensin-2 complex subunit D3
Gene Name	NCAPD3
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1196	KLISQVQKKNLIENI
1425	TPFPVKGKSLPNRPT

Function

Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size

Protein Sequence

10 MAARQGLESS 20 LQPWNTLDLS 30 PEWVDAVWEV 40 EFTETEPLDP 50 GIEAEIEESG 60 LRAFTDLYDS 70 LFSFATEEHG 80 ATESIWTFFA 90 ENNISHKALM 100 AVFYHFVQKV 110 HKKNVNVKQR 120 KFGLHAAALY 130 FLLLEVPGSV 140 ANQVFHPVMF 150 DKCVQILKKS 160 WPQESSLSQK 170 RKKEQPKNSQ 180 ANPRGNKKRG 190 RPLRKESLEM 200 DEIIEEQEDE 210 ESIFFSAWDL 220 CQIRNAIFDL 230 LKNFLRLLPR 240 FSLKEKPQCV 250 QNCIEVFVAL 260 TNLEPVPREF 270 HVTQARNPNQ 280 AKYIPELAYH 290 GLYLMCSPFH 300 GEGDKVIRCV 310 FHQMLYLILM 320 LEVGEGSHHA 330 PLTITPTVIN 340 GRNLAVQFIS 350 SLVDELKEGI 360 FPVLRILLQH 370 ICVKVVDKSE 380 YRTYAAQSLV 390 QLLNKLPCAE 400 YASFIAWFYG 410 CSRNPKTSRR 420 VFTLDVALAL 430 LELPEREVEG 440 TLPPEHQKFL 450 KHKFLVQEIL 460 FARCVDKAPA 470 VRSKALSSFA 480 HCLEFSSTAT 490 SESVLGLLID 500 SPTISGIESN 510 RDTSLKNSSA 520 FSYQKKTLNP 530 SGSSEVINID 540 NSGETAGSSE 550 MCLMTMLKSR 560 MGDEKANVRK 570 SALQVLVSVL 580 KHCDVSGLKE 590 ELSILQDHCR 600 DIALSVRKQA 610 LQSLTELLVA 620 QPRCVQIQKA 630 WLWGVIPAVM 640 DSERTVQDKA 650 LECLDQLLLQ 660 NIQHHSQFHH 670 EDDSQVLTWA 680 LLSLLSTESQ 690 ELGRYLNKAF 700 QGWSKKEKFS 710 STFVNNVLSH 720 TGKEHCAPAW 730 MLLSKVVCSA 740 PTLDHTKIMK 750 SWEQMSRQPN 760 PNADTLGHIL 770 CVIGHIAKHL 780 PKSTRDKVTN 790 VVEQKLSGFQ 800 WSPKLIKPAV 810 DTLQHLCRAS 820 AETPVEEQKL 830 LAQVCGDILS 840 TCVHCLSDVL 850 LKEDGTRRMN 860 EDLVVKYIFT 870 LGDVAQLCPA 880 RVDKRAFLLI 890 QSILAASPST 900 DHLPASDPGG 910 SEATASQPLP 920 GIHSSIMPSV 930 IRAHAVIALG 940 KLCLQHEDLA 950 KRSIPALVRE 960 LEVCSDMAVR 970 NNVVITMCDL 980 CKRYTAMVDK 990 YIPNISACLK 1000 DSEPFIRRQT 1010 LLLLTDLLQE 1020 DFVKWKGPLF 1030 FRFVSTLVDP 1040 DLAIASTGKF 1050 CLAQLLLKRN 1060 PAMFFQHFNE 1070 CIFHFNSYEK 1080 HEKYNRFPQS 1090 EREKRLFSLK 1100 GKTNKEKRMK 1110 IYSFLLEHFT 1120 DEQRFNITSK 1130 ICLSTLACFA 1140 DGILPLDMEA 1150 SELLSDTFEV 1160 LSSKEIKLLA 1170 MRNKVDKDLP 1180 VEEEDLALAN 1190 VVLQEAQKKL 1200 ISQVQKKNLI 1210 ENIIPVIISL 1220 KTVLEKNKIP 1230 ALRDLMHYLR 1240 EVMQDYRAEI 1250 EEFFASDTQL 1260 ASELEYDMKQ 1270 YQEQEQMEQE 1280 LISSSEKIPA 1290 PTSLESTMAN 1300 VASQPSTSRP 1310 RTAHAPAPLS 1320 LDTRPLKRLM 1330 PKASHRSMSP 1340 STIAILNSVK 1350 KAVESNSQHR 1360 SRSLGLPPFT 1370 VCPKSLGEPS 1380 EGASSQDLER 1390 ESSGAIDLLT 1400 KRGISTPERT 1410 IQNVTFGTGL 1420 SCVGSPQTPF 1430 PVKGKSLPNR 1440 PTSRVCELGS 1450 LGACETLSED 1460 MEAQGQRDVL 1470 CLSLPDMTPP 1480 QPAQWNVTSP 1490 ARGRDSAAPR 1500 RSRRKAPLKT AN

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000779	condensed chromosome, centromeric region
Cellular Component	GO:0000796	condensin complex
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005721	pericentric heterochromatin
Molecular Function	GO:0042393	histone binding
Molecular Function	GO:0140117	histone H4K20me1 reader activity
Biological Process	GO:0051301	cell division
Biological Process	GO:0010032	meiotic chromosome condensation
Biological Process	GO:0007076	mitotic chromosome condensation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.