Search Results
Overview
| Uniprot ID | M3VH35 |
|---|---|
| Protein Name | Delta(14)-sterol reductase LBR |
| Gene Name | LBR |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 111 | ADRKEVRKEILEVKL |
| 64 | LTSFRQRKSGSASSS |
Function
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation. Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation. Anchors the lamina and the heterochromatin to the inner nuclear membrane
Protein Sequence
10
MPTRRFADGE
20
VVRGRWPGSS
30
LYYEVEILSH
40
DSKSQLYTVK
50
YKDGTELELK
60
ESDIKPLTSF
70
RQRKSGSASS
80
SPSRRRGSRS
90
RSRSRSPGRP
100
PRSSRRSASA
110
SHQADRKEVR
120
KEILEVKLTP
130
LVLKPFGNSI
140
NRYNGEPEHR
150
EKNDLPHKTT
160
QVHTGSFSLQ
170
EKFHLPQESS
180
YLSTQYSLRP
190
RREEIKLKEI
200
DAQEEKIVTE
210
GPTSLRTFEV
220
TTKQLKEVEF
230
GGVPGVLTIM
240
LGLPAFLFLL
250
LLMCKQKEPS
260
LLNFPPPLPA
270
LSDLWDARVF
280
GLYLVWFFLQ
290
ALFYLLPIGK
300
VVEGTPLADG
310
RRLKYRLNGF
320
YAFILTSGLV
330
GASLLWDVEL
340
YYVYNHFLQF
350
ALAATVWAVV
360
LSVYLCARAL
370
KAPRNDLSPA
380
SSGNAIYDFF
390
IGRELNPRIG
400
TFDLKYFCEL
410
RPGLIGWVVI
420
NLVMLLAEMK
430
VQNRAFPSLA
440
MILVNSFQLL
450
YVVDALWNEE
460
ALLTTMDIIH
470
DGFGFMLAFG
480
DLVWVPFIYS
490
FQAFYLVAHP
500
NELSWPAASL
510
IVALKLCGFI
520
IFRCANSQKN
530
AFRKNPNDPK
540
LAHLKTIHTS
550
TGKNLLVSGW
560
WGFVRHPNYL
570
GDLIMALAWS
580
LPCGFSHILP
590
YFYVIYFTAL
600
LVHREARDEH
610
HCKRKYGLAW
620
EKYCQRVPYR
IFPHIY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005637 | nuclear inner membrane |
| Cellular Component | GO:0005652 | nuclear lamina |
| Molecular Function | GO:0140463 | chromatin-protein adaptor activity |
| Molecular Function | GO:0070087 | chromo shadow domain binding |
| Molecular Function | GO:0050613 | Delta14-sterol reductase activity |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0070402 | NADPH binding |
| Biological Process | GO:0006695 | cholesterol biosynthetic process |
| Biological Process | GO:0033489 | cholesterol biosynthetic process via desmosterol |
| Biological Process | GO:0030223 | neutrophil differentiation |
| Biological Process | GO:0060816 | random inactivation of X chromosome |
| Biological Process | GO:0036197 | zymosterol biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.