Search Results
Overview
| Uniprot ID | M3VJZ7 |
|---|---|
| Protein Name | LIM and SH3 domain protein 1 |
| Gene Name | LASP1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 10 | PNCARCGKIVYPTEK |
| 112 | PELQRIKKTQDQISN |
| 121 | QDQISNIKYHEEFEK |
| 128 | KYHEEFEKSRMGPSG |
| 17 | KIVYPTEKVNCLDKF |
| 23 | EKVNCLDKFWHKACF |
| 27 | CLDKFWHKACFHCET |
| 45 | TLNMKNYKGYEKKPY |
| 49 | KNYKGYEKKPYCNAH |
| 50 | NYKGYEKKPYCNAHY |
| 75 | TPENLRLKQQSELQS |
| 87 | LQSQVRYKEEFEKNK |
| 96 | EFEKNKGKGFSVVAD |
Function
Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types
Protein Sequence
10
MNPNCARCGK
20
IVYPTEKVNC
30
LDKFWHKACF
40
HCETCKMTLN
50
MKNYKGYEKK
60
PYCNAHYPKQ
70
SFTMVADTPE
80
NLRLKQQSEL
90
QSQVRYKEEF
100
EKNKGKGFSV
110
VADTPELQRI
120
KKTQDQISNI
130
KYHEEFEKSR
140
MGPSGGEGLE
150
PERRDAQDTS
160
YRRPQEQQQP
170
HHIPTSTPVY
180
QQPQQQQAAQ
190
SYGGYKEPAA
200
PVSIQRSAPG
210
GGGKRYRAVY
220
DYSAADEDEV
230
SFQDGDTIVN
240
VQQIDDGWMY
250
GTVERTGDTG
260
MLPANYVEAI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005925 | focal adhesion |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006811 | monoatomic ion transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.