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Overview

Uniprot ID	M4XYZ9
Protein Name	Endoplasmic reticulum chaperone BIP
Gene Name	LOC113215650
Organism	Frankliniella occidentalis

Kla Sites from experimental identification

Position	Flanking peptide
164	TAEAYLGKKVTHAVV
165	AEAYLGKKVTHAVVT
371	GGSTRIPKVQQLVKE
524	KGTGNREKIVITNDQ

Function

Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins. Acts as a key repressor of the unfolded protein response (UPR)

Protein Sequence

10 MKLILASVLC 20 LLVANSLASK 30 DEKDKAKEVG 40 TVIGIDLGTT 50 YSCVGVYKNG 60 RVEIIANDQG 70 NRITPSYVAF 80 TAEGERLIGD 90 AAKNQLTSNP 100 ENTVFDAKRL 110 IGREWTDATV 120 QADIKFFPFK 130 VIEKNSKPHV 140 VVKTGQGDKT 150 FAPEEISAMV 160 LGKMKETAEA 170 YLGKKVTHAV 180 VTVPAYFNDA 190 QRQATKDAGT 200 ISGLNVMRII 210 NEPTAAAIAY 220 GLDKREGEKN 230 VLVFDLGGGT 240 FDVSLLTIDN 250 GVFEVVSTNG 260 DTHLGGEDFD 270 QRVMDHFIKL 280 YKKKKGKDIR 290 KDNRAVQKLR 300 REVEKAKRAL 310 SSSHQVRIEI 320 ESFFEGDDFS 330 ETLTRAKFEE 340 LNMDLFRSTM 350 KPVQKVLEDA 360 DMNKKDVDEI 370 VLVGGSTRIP 380 KVQQLVKEFF 390 NNKEPSRGIN 400 PDEAVAYGAA 410 VQAGVLSGEQ 420 DTDAIVLLDV 430 NPLTLGIETV 440 GGVMTKLIPR 450 NTVIPTKKSQ 460 IFSTAADNQH 470 TVTIQVYEGE 480 RPMTKDNHQL 490 GKFDLTGIPP 500 APRGVPQIEV 510 TFEIDANGIL 520 QVSAEDKGTG 530 NREKIVITND 540 QNRLTPEDID 550 RMIKDAERFS 560 DDDKKLKERV 570 EARNELESYA 580 YSLKNQLGDK 590 DKLGAKLSDS 600 DKTKMEEAIE 610 EKIKWLDENQ 620 DTDTEAYRKQ 630 KKELEEVVQP 640 IITKLYQGAG 650 GAGGAPPPSN 660 ADDDELKDEL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005788	endoplasmic reticulum lumen
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Biological Process	GO:0034976	response to endoplasmic reticulum stress

Reference

[1] An D, Song L, Li Y, Shen L, Miao P et al.. Comprehensive analysis of lysine lactylation in Frankliniella occidentalis.. Front Genet 13:1014225. 2022. PMID: 36386791.