Search Results

Overview

Uniprot IDO00139
Protein NameKinesin-like protein KIF2A
Gene NameKIF2A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
102 RRTVASIKNDPPSRD
161 RRKSNCVKEVEKLQE
165 NCVKEVEKLQEKREK
169 EVEKLQEKREKRRLQ
330 MGGDFSGKNQDCSKG

Function

Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity

Protein Sequence

10 MATANFGKIQ 20 IGIYVEIKRS 30 DGRIHQAMVT 40 SLNEDNESVT 50 VEWIENGDTK 60 GKEIDLESIF 70 SLNPDLVPDE 80 EIEPSPETPP 90 PPASSAKVNK 100 IVKNRRTVAS 110 IKNDPPSRDN 120 RVVGSARARP 130 SQFPEQSSSA 140 QQNGSVSDIS 150 PVQAAKKEFG 160 PPSRRKSNCV 170 KEVEKLQEKR 180 EKRRLQQQEL 190 REKRAQDVDA 200 TNPNYEIMCM 210 IRDFRGSLDY 220 RPLTTADPID 230 EHRICVCVRK 240 RPLNKKETQM 250 KDLDVITIPS 260 KDVVMVHEPK 270 QKVDLTRYLE 280 NQTFRFDYAF 290 DDSAPNEMVY 300 RFTARPLVET 310 IFERGMATCF 320 AYGQTGSGKT 330 HTMGGDFSGK 340 NQDCSKGIYA 350 LAARDVFLML 360 KKPNYKKLEL 370 QVYATFFEIY 380 SGKVFDLLNR 390 KTKLRVLEDG 400 KQQVQVVGLQ 410 EREVKCVEDV 420 LKLIDIGNSC 430 RTSGQTSANA 440 HSSRSHAVFQ 450 IILRRKGKLH 460 GKFSLIDLAG 470 NERGADTSSA 480 DRQTRLEGAE 490 INKSLLALKE 500 CIRALGRNKP 510 HTPFRASKLT 520 QVLRDSFIGE 530 NSRTCMIATI 540 SPGMASCENT 550 LNTLRYANRV 560 KELTVDPTAA 570 GDVRPIMHHP 580 PNQIDDLETQ 590 WGVGSSPQRD 600 DLKLLCEQNE 610 EEVSPQLFTF 620 HEAVSQMVEM 630 EEQVVEDHRA 640 VFQESIRWLE 650 DEKALLEMTE 660 EVDYDVDSYA 670 TQLEAILEQK 680 IDILTELRDK 690 VKSFRAALQE 700 EEQASKQINP KRPRAL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0120103 centriolar subdistal appendage
Cellular Component GO:0005814 centriole
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005871 kinesin complex
Cellular Component GO:0016020 membrane
Cellular Component GO:0005874 microtubule
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005819 spindle
Cellular Component GO:0000922 spindle pole
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0003774 cytoskeletal motor activity
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0003777 microtubule motor activity
Biological Process GO:0030154 cell differentiation
Biological Process GO:0051301 cell division
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0007019 microtubule depolymerization
Biological Process GO:0007018 microtubule-based movement
Biological Process GO:0090307 mitotic spindle assembly
Biological Process GO:0007052 mitotic spindle organization
Biological Process GO:0007399 nervous system development
Biological Process GO:0030334 regulation of cell migration

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.