Search Results

Overview

Uniprot IDO00151
Protein NamePDZ and LIM domain protein 1
Gene NamePDLIM1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
103 EGKRHPYKMNLASEP
22 GFRLVGGKDFEQPLA
241 PSGFRSVKAPVTKVA
246 SVKAPVTKVAASIGN
256 ASIGNAQKLPMCDKC
309 EDQIYCEKHARERVT
329 EVVTVFPK*******
71 LEAQNRIKGCTDNLT
87 TVARSEHKVWSPLVT
98 PLVTEEGKRHPYKMN

Function

Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (PubMed:10861853). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity)

Protein Sequence

10 MTTQQIDLQG 20 PGPWGFRLVG 30 GKDFEQPLAI 40 SRVTPGSKAA 50 LANLCIGDVI 60 TAIDGENTSN 70 MTHLEAQNRI 80 KGCTDNLTLT 90 VARSEHKVWS 100 PLVTEEGKRH 110 PYKMNLASEP 120 QEVLHIGSAH 130 NRSAMPFTAS 140 PASSTTARVI 150 TNQYNNPAGL 160 YSSENISNFN 170 NALESKTAAS 180 GVEANSRPLD 190 HAQPPSSLVI 200 DKESEVYKML 210 QEKQELNEPP 220 KQSTSFLVLQ 230 EILESEEKGD 240 PNKPSGFRSV 250 KAPVTKVAAS 260 IGNAQKLPMC 270 DKCGTGIVGV 280 FVKLRDRHRH 290 PECYVCTDCG 300 TNLKQKGHFF 310 VEDQIYCEKH 320 ARERVTPPEG YEVVTVFPK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0031941 filamentous actin
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0001725 stress fiber
Cellular Component GO:0005667 transcription regulator complex
Cellular Component GO:0030018 Z disc
Molecular Function GO:0003779 actin binding
Molecular Function GO:0098641 cadherin binding involved in cell-cell adhesion
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0051371 muscle alpha-actinin binding
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0030950 establishment or maintenance of actin cytoskeleton polarity
Biological Process GO:0010761 fibroblast migration
Biological Process GO:0007507 heart development
Biological Process GO:0030011 maintenance of cell polarity
Biological Process GO:0061061 muscle structure development
Biological Process GO:0001666 response to hypoxia
Biological Process GO:0006979 response to oxidative stress
Biological Process GO:0043149 stress fiber assembly

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[4] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[5] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[6] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[7] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[8] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[9] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.