Search Results
Overview
| Uniprot ID | O00154 |
|---|---|
| Protein Name | Cytosolic acyl coenzyme A thioester hydrolase |
| Gene Name | ACOT7 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 172 | LSLKNVDKVLEVPPV |
| 198 | RKRYEAQKLERMETK |
| 355 | VPETEDEKKRFEEGK |
Function
Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:10578051). Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (PubMed:10578051). May play an important physiological function in brain (PubMed:10578051)
Protein Sequence
10
MKLLARALRL
20
CEFGRQASSR
30
RLVAGQGCVG
40
PRRGCCAPVQ
50
VVGPRADLPP
60
CGACITGRIM
70
RPDDANVAGN
80
VHGGTILKMI
90
EEAGAIISTR
100
HCNSQNGERC
110
VAALARVERT
120
DFLSPMCIGE
130
VAHVSAEITY
140
TSKHSVEVQV
150
NVMSENILTG
160
AKKLTNKATL
170
WYVPLSLKNV
180
DKVLEVPPVV
190
YSRQEQEEEG
200
RKRYEAQKLE
210
RMETKWRNGD
220
IVQPVLNPEP
230
NTVSYSQSSL
240
IHLVGPSDCT
250
LHGFVHGGVT
260
MKLMDEVAGI
270
VAARHCKTNI
280
VTASVDAINF
290
HDKIRKGCVI
300
TISGRMTFTS
310
NKSMEIEVLV
320
DADPVVDSSQ
330
KRYRAASAFF
340
TYVSLSQEGR
350
SLPVPQLVPE
360
TEDEKKRFEE
370
GKGRYLQMKA
380
KRQGHAEPQP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0052689 | carboxylic ester hydrolase activity |
| Molecular Function | GO:0000062 | fatty-acyl-CoA binding |
| Molecular Function | GO:0036042 | long-chain fatty acyl-CoA binding |
| Molecular Function | GO:0052816 | long-chain fatty acyl-CoA hydrolase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0006637 | acyl-CoA metabolic process |
| Biological Process | GO:0015937 | coenzyme A biosynthetic process |
| Biological Process | GO:0009062 | fatty acid catabolic process |
| Biological Process | GO:0036116 | long-chain fatty-acyl-CoA catabolic process |
| Biological Process | GO:0051792 | medium-chain fatty acid biosynthetic process |
| Biological Process | GO:0036114 | medium-chain fatty-acyl-CoA catabolic process |
| Biological Process | GO:1900535 | palmitic acid biosynthetic process |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.