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Overview

Uniprot IDO00159
Protein NameUnconventional myosin-Ic
Gene NameMYO1C
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
486 ICDLVEEKFKGIISI
594 DRSELSDKKRPETVA
667 AGFAYRRKYEAFLQR
781 RRKAAKRKWAAQTIR
885 SEIFKGKKDNYPQSV

Function

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes

Protein Sequence

10 MALQVELVPT 20 GEIIRVVHPH 30 RPCKLALGSD 40 GVRVTMESAL 50 TARDRVGVQD 60 FVLLENFTSE 70 AAFIENLRRR 80 FRENLIYTYI 90 GPVLVSVNPY 100 RDLQIYSRQH 110 MERYRGVSFY 120 EVPPHLFAVA 130 DTVYRALRTE 140 RRDQAVMISG 150 ESGAGKTEAT 160 KRLLQFYAET 170 CPAPERGGAV 180 RDRLLQSNPV 190 LEAFGNAKTL 200 RNDNSSRFGK 210 YMDVQFDFKG 220 APVGGHILSY 230 LLEKSRVVHQ 240 NHGERNFHIF 250 YQLLEGGEEE 260 TLRRLGLERN 270 PQSYLYLVKG 280 QCAKVSSIND 290 KSDWKVVRKA 300 LTVIDFTEDE 310 VEDLLSIVAS 320 VLHLGNIHFA 330 ANEESNAQVT 340 TENQLKYLTR 350 LLSVEGSTLR 360 EALTHRKIIA 370 KGEELLSPLN 380 LEQAAYARDA 390 LAKAVYSRTF 400 TWLVGKINRS 410 LASKDVESPS 420 WRSTTVLGLL 430 DIYGFEVFQH 440 NSFEQFCINY 450 CNEKLQQLFI 460 ELTLKSEQEE 470 YEAEGIAWEP 480 VQYFNNKIIC 490 DLVEEKFKGI 500 ISILDEECLR 510 PGEATDLTFL 520 EKLEDTVKHH 530 PHFLTHKLAD 540 QRTRKSLGRG 550 EFRLLHYAGE 560 VTYSVTGFLD 570 KNNDLLFRNL 580 KETMCSSKNP 590 IMSQCFDRSE 600 LSDKKRPETV 610 ATQFKMSLLQ 620 LVEILQSKEP 630 AYVRCIKPND 640 AKQPGRFDEV 650 LIRHQVKYLG 660 LLENLRVRRA 670 GFAYRRKYEA 680 FLQRYKSLCP 690 ETWPTWAGRP 700 QDGVAVLVRH 710 LGYKPEEYKM 720 GRTKIFIRFP 730 KTLFATEDAL 740 EVRRQSLATK 750 IQAAWRGFHW 760 RQKFLRVKRS 770 AICIQSWWRG 780 TLGRRKAAKR 790 KWAAQTIRRL 800 IRGFVLRHAP 810 RCPENAFFLD 820 HVRTSFLLNL 830 RRQLPQNVLD 840 TSWPTPPPAL 850 REASELLREL 860 CIKNMVWKYC 870 RSISPEWKQQ 880 LQQKAVASEI 890 FKGKKDNYPQ 900 SVPRLFISTR 910 LGTDEISPRV 920 LQALGSEPIQ 930 YAVPVVKYDR 940 KGYKPRSRQL 950 LLTPNAVVIV 960 EDAKVKQRID 970 YANLTGISVS 980 SLSDSLFVLH 990 VQRADNKQKG 1000 DVVLQSDHVI 1010 ETLTKTALSA 1020 NRVNSININQ 1030 GSITFAGGPG 1040 RDGTIDFTPG 1050 SELLITKAKN 1060 GHLAVVAPRL NSR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0009925 basal plasma membrane
Cellular Component GO:0005903 brush border
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0030659 cytoplasmic vesicle membrane
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031941 filamentous actin
Cellular Component GO:0016328 lateral plasma membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0005902 microvillus
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0045335 phagocytic vesicle
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0032587 ruffle membrane
Cellular Component GO:0060171 stereocilium membrane
Cellular Component GO:0016461 unconventional myosin complex
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0000146 microfilament motor activity
Molecular Function GO:0005102 signaling receptor binding
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0007015 actin filament organization
Biological Process GO:0030048 actin filament-based movement
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006897 endocytosis
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0045943 positive regulation of transcription by RNA polymerase I
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0045945 positive regulation of transcription by RNA polymerase III
Biological Process GO:0006612 protein targeting to membrane
Biological Process GO:2000810 regulation of bicellular tight junction assembly
Biological Process GO:0038084 vascular endothelial growth factor signaling pathway

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.