Search Results

Overview

Uniprot ID	O00170
Protein Name	AH receptor-interacting protein
Gene Name	AIP
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
112	LRNIAVGKDPLEGQR

Function

May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting

Protein Sequence

10 MADIIARLRE 20 DGIQKRVIQE 30 GRGELPDFQD 40 GTKATFHYRT 50 LHSDDEGTVL 60 DDSRARGKPM 70 ELIIGKKFKL 80 PVWETIVCTM 90 REGEIAQFLC 100 DIKHVVLYPL 110 VAKSLRNIAV 120 GKDPLEGQRH 130 CCGVAQMREH 140 SSLGHADLDA 150 LQQNPQPLIF 160 HMEMLKVESP 170 GTYQQDPWAM 180 TDEEKAKAVP 190 LIHQEGNRLY 200 REGHVKEAAA 210 KYYDAIACLK 220 NLQMKEQPGS 230 PEWIQLDQQI 240 TPLLLNYCQC 250 KLVVEEYYEV 260 LDHCSSILNK 270 YDDNVKAYFK 280 RGKAHAAVWN 290 AQEAQADFAK 300 VLELDPALAP 310 VVSRELRALE 320 ARIRQKDEED 330 KARFRGIFSH

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0034751	aryl hydrocarbon receptor complex
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005654	nucleoplasm
Molecular Function	GO:0017162	aryl hydrocarbon receptor binding
Molecular Function	GO:0036004	GAF domain binding
Molecular Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
Molecular Function	GO:0003713	transcription coactivator activity
Molecular Function	GO:0051082	unfolded protein binding
Biological Process	GO:0051604	protein maturation
Biological Process	GO:0006626	protein targeting to mitochondrion

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[3] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.