Search Results

Overview

Uniprot IDO00193
Protein NameSmall acidic protein
Gene NameSMAP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
13 ESHPHGVKRSASPDD
170 PKNKKDAKSNYKMMF
174 KDAKSNYKMMFVKSS
40 GNEERKQKFLRLMGA
49 LRLMGAGKKEHTGRL
50 RLMGAGKKEHTGRLV
62 RLVIGDHKSTSHFRT
91 YQQSMDSKLSGRYRR

Function

No function data available.

Protein Sequence

10 MSAARESHPH 20 GVKRSASPDD 30 DLGSSNWEAA 40 DLGNEERKQK 50 FLRLMGAGKK 60 EHTGRLVIGD 70 HKSTSHFRTG 80 EEDKKINEEL 90 ESQYQQSMDS 100 KLSGRYRRHC 110 GLGFSEVEDH 120 DGEGDVAGDD 130 DDDDDDSPDP 140 ESPDDSESDS 150 ESEKEESAEE 160 LQAAEHPDEV 170 EDPKNKKDAK 180 SNYKMMFVKS SGS

Gene Ontology

No Gene Ontology data available.

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[6] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[7] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[8] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[9] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[10] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.