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Overview

Uniprot ID	O00203
Protein Name	AP-3 complex subunit beta-1
Gene Name	AP3B1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
665	KEWTPAGKAKQENSA
667	WTPAGKAKQENSAKK

Function

Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals

Protein Sequence

10 MSSNSFPYNE 20 QSGGGEATEL 30 GQEATSTISP 40 SGAFGLFSSD 50 LKKNEDLKQM 60 LESNKDSAKL 70 DAMKRIVGMI 80 AKGKNASELF 90 PAVVKNVASK 100 NIEIKKLVYV 110 YLVRYAEEQQ 120 DLALLSISTF 130 QRALKDPNQL 140 IRASALRVLS 150 SIRVPIIVPI 160 MMLAIKEASA 170 DLSPYVRKNA 180 AHAIQKLYSL 190 DPEQKEMLIE 200 VIEKLLKDKS 210 TLVAGSVVMA 220 FEEVCPDRID 230 LIHKNYRKLC 240 NLLVDVEEWG 250 QVVIIHMLTR 260 YARTQFVSPW 270 KEGDELEDNG 280 KNFYESDDDQ 290 KEKTDKKKKP 300 YTMDPDHRLL 310 IRNTKPLLQS 320 RNAAVVMAVA 330 QLYWHISPKS 340 EAGIISKSLV 350 RLLRSNREVQ 360 YIVLQNIATM 370 SIQRKGMFEP 380 YLKSFYVRST 390 DPTMIKTLKL 400 EILTNLANEA 410 NISTLLREFQ 420 TYVKSQDKQF 430 AAATIQTIGR 440 CATNILEVTD 450 TCLNGLVCLL 460 SNRDEIVVAE 470 SVVVIKKLLQ 480 MQPAQHGEII 490 KHMAKLLDSI 500 TVPVARASIL 510 WLIGENCERV 520 PKIAPDVLRK 530 MAKSFTSEDD 540 LVKLQILNLG 550 AKLYLTNSKQ 560 TKLLTQYILN 570 LGKYDQNYDI 580 RDRTRFIRQL 590 IVPNVKSGAL 600 SKYAKKIFLA 610 QKPAPLLESP 620 FKDRDHFQLG 630 TLSHTLNIKA 640 TGYLELSNWP 650 EVAPDPSVRN 660 VEVIELAKEW 670 TPAGKAKQEN 680 SAKKFYSESE 690 EEEDSSDSSS 700 DSESESGSES 710 GEQGESGEEG 720 DSNEDSSEDS 730 SSEQDSESGR 740 ESGLENKRTA 750 KRNSKAKGKS 760 DSEDGEKENE 770 KSKTSDSSND 780 ESSSIEDSSS 790 DSESESEPES 800 ESESRRVTKE 810 KEKKTKQDRT 820 PLTKDVSLLD 830 LDDFNPVSTP 840 VALPTPALSP 850 SLMADLEGLH 860 LSTSSSVISV 870 STPAFVPTKT 880 HVLLHRMSGK 890 GLAAHYFFPR 900 QPCIFGDKMV 910 SIQITLNNTT 920 DRKIENIHIG 930 EKKLPIGMKM 940 HVFNPIDSLE 950 PEGSITVSMG 960 IDFCDSTQTA 970 SFQLCTKDDC 980 FNVNIQPPVG 990 ELLLPVAMSE 1000 KDFKKEQGVL 1010 TGMNETSAVI 1020 IAAPQNFTPS 1030 VIFQKVVNVA 1040 NVGAVPSGQD 1050 NIHRFAAKTV 1060 HSGSLMLVTV 1070 ELKEGSTAQL 1080 IINTEKTVIG 1090 SVLLRELKPV LSQG

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0030123	AP-3 adaptor complex
Cellular Component	GO:1904115	axon cytoplasm
Cellular Component	GO:0030131	clathrin adaptor complex
Cellular Component	GO:0030665	clathrin-coated vesicle membrane
Cellular Component	GO:0005769	early endosome
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0005765	lysosomal membrane
Cellular Component	GO:0016020	membrane
Cellular Component	GO:1990742	microvesicle
Molecular Function	GO:0030742	GTP-dependent protein binding
Molecular Function	GO:0019903	protein phosphatase binding
Biological Process	GO:0008089	anterograde axonal transport
Biological Process	GO:0048490	anterograde synaptic vesicle transport
Biological Process	GO:0035654	clathrin-coated vesicle cargo loading, AP-3-mediated
Biological Process	GO:0006886	intracellular protein transport
Biological Process	GO:1903232	melanosome assembly
Biological Process	GO:0032438	melanosome organization
Biological Process	GO:0060155	platelet dense granule organization
Biological Process	GO:0016192	vesicle-mediated transport

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.