Overview
| Uniprot ID | O00213 |
|---|
| Protein Name | Amyloid beta precursor protein binding family B member 1 |
|---|
| Gene Name | APBB1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 542 |
PKNELVQKFQVYYLG |
| 555 |
LGNVPVAKPVGVDVI |
| 68 |
EPGPANAKWLKEGQN |
Function
Transcription coregulator that can have both coactivator and corepressor functions (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469, PubMed:33938178). Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469). Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469). May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1 (PubMed:19234442). Required for histone H4 acetylation at double-strand breaks (DSBs) (PubMed:19234442). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity (PubMed:33938178). Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4 (PubMed:19343227). Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity). Plays a role in the maintenance of lens transparency (By similarity). May play a role in muscle cell strength (By similarity). Acts as a molecular adapter that functions in neurite outgrowth by activating the RAC1-ARF6 axis upon insulin treatment (PubMed:36250347)
Protein Sequence
10
MSVPSSLSQS
20
AINANSHGGP
30
ALSLPLPLHA
40
AHNQLLNAKL
50
QATAVGPKDL
60
RSAMGEGGGP
70
EPGPANAKWL
80
KEGQNQLRRA
90
ATAHRDQNRN
100
VTLTLAEEAS
110
QEPEMAPLGP
120
KGLIHLYSEL
130
ELSAHNAANR
140
GLRGPGLIIS
150
TQEQGPDEGE
160
EKAAGEAEEE
170
EEDDDDEEEE
180
EDLSSPPGLP
190
EPLESVEAPP
200
RPQALTDGPR
210
EHSKSASLLF
220
GMRNSAASDE
230
DSSWATLSQG
240
SPSYGSPEDT
250
DSFWNPNAFE
260
TDSDLPAGWM
270
RVQDTSGTYY
280
WHIPTGTTQW
290
EPPGRASPSQ
300
GSSPQEESQL
310
TWTGFAHGEG
320
FEDGEFWKDE
330
PSDEAPMELG
340
LKEPEEGTLT
350
FPAQSLSPEP
360
LPQEEEKLPP
370
RNTNPGIKCF
380
AVRSLGWVEM
390
TEEELAPGRS
400
SVAVNNCIRQ
410
LSYHKNNLHD
420
PMSGGWGEGK
430
DLLLQLEDET
440
LKLVEPQSQA
450
LLHAQPIISI
460
RVWGVGRDSG
470
RERDFAYVAR
480
DKLTQMLKCH
490
VFRCEAPAKN
500
IATSLHEICS
510
KIMAERRNAR
520
CLVNGLSLDH
530
SKLVDVPFQV
540
EFPAPKNELV
550
QKFQVYYLGN
560
VPVAKPVGVD
570
VINGALESVL
580
SSSSREQWTP
590
SHVSVAPATL
600
TILHQQTEAV
610
LGECRVRFLS
620
FLAVGRDVHT
630
FAFIMAAGPA
640
SFCCHMFWCE
650
PNAASLSEAV
660
QAACMLRYQK
670
CLDARSQAST
680
SCLPAPPAES
690
VARRVGWTVR
700
RGVQSLWGSL
710
KPKRLGAHTP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0030426 |
growth cone |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0001540 |
amyloid-beta binding |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Molecular Function |
GO:0042393 |
histone binding |
| Molecular Function |
GO:0050750 |
low-density lipoprotein particle receptor binding |
| Molecular Function |
GO:0060090 |
molecular adaptor activity |
| Molecular Function |
GO:0070064 |
proline-rich region binding |
| Molecular Function |
GO:0003713 |
transcription coactivator activity |
| Molecular Function |
GO:0031625 |
ubiquitin protein ligase binding |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0007409 |
axonogenesis |
| Biological Process |
GO:0006325 |
chromatin organization |
| Biological Process |
GO:0006974 |
DNA damage response |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:1902807 |
negative regulation of cell cycle G1/S phase transition |
| Biological Process |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0043065 |
positive regulation of apoptotic process |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
| Biological Process |
GO:0010976 |
positive regulation of neuron projection development |
| Biological Process |
GO:0050714 |
positive regulation of protein secretion |
| Biological Process |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
| Biological Process |
GO:0007165 |
signal transduction |
| Biological Process |
GO:0006939 |
smooth muscle contraction |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.