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Overview

Uniprot IDO00231
Protein Name26S proteasome non-ATPase regulatory subunit 11
Gene NamePSMD11
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
295 KCVAQASKNRSLADF
32 DILHSIVKRDIQEND
417 VVDSLYNKAKKLT**

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity

Protein Sequence

10 MAAAAVVEFQ 20 RAQSLLSTDR 30 EASIDILHSI 40 VKRDIQENDE 50 EAVQVKEQSI 60 LELGSLLAKT 70 GQAAELGGLL 80 KYVRPFLNSI 90 SKAKAARLVR 100 SLLDLFLDME 110 AATGQEVELC 120 LECIEWAKSE 130 KRTFLRQALE 140 ARLVSLYFDT 150 KRYQEALHLG 160 SQLLRELKKM 170 DDKALLVEVQ 180 LLESKTYHAL 190 SNLPKARAAL 200 TSARTTANAI 210 YCPPKLQATL 220 DMQSGIIHAA 230 EEKDWKTAYS 240 YFYEAFEGYD 250 SIDSPKAITS 260 LKYMLLCKIM 270 LNTPEDVQAL 280 VSGKLALRYA 290 GRQTEALKCV 300 AQASKNRSLA 310 DFEKALTDYR 320 AELRDDPIIS 330 THLAKLYDNL 340 LEQNLIRVIE 350 PFSRVQIEHI 360 SSLIKLSKAD 370 VERKLSQMIL 380 DKKFHGILDQ 390 GEGVLIIFDE 400 PPVDKTYEAA 410 LETIQNMSKV 420 VDSLYNKAKK LT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0022624 proteasome accessory complex
Cellular Component GO:0000502 proteasome complex
Cellular Component GO:0008541 proteasome regulatory particle, lid subcomplex
Cellular Component GO:0034774 secretory granule lumen
Cellular Component GO:0008021 synaptic vesicle
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0071357 cellular response to type I interferon
Biological Process GO:0010498 proteasomal protein catabolic process
Biological Process GO:0043248 proteasome assembly
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0061136 regulation of proteasomal protein catabolic process
Biological Process GO:0006979 response to oxidative stress
Biological Process GO:0048863 stem cell differentiation
Biological Process GO:0006511 ubiquitin-dependent protein catabolic process

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.