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Overview

Uniprot IDO00232
Protein Name26S proteasome non-ATPase regulatory subunit 12
Gene NamePSMD12
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
221 FQEENTEKLKLKYYN
223 EENTEKLKLKYYNLM
268 EKWQQALKSVVLYVI
301 KKLEEIPKYKDLLKL
405 VNKTIFAKVDRLAGI
419 IINFQRPKDPNNLLN
98 SKRRSQLKQAVAKMV

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair

Protein Sequence

10 MADGGSERAD 20 GRIVKMEVDY 30 SATVDQRLPE 40 CAKLAKEGRL 50 QEVIETLLSL 60 EKQTRTASDM 70 VSTSRILVAV 80 VKMCYEAKEW 90 DLLNENIMLL 100 SKRRSQLKQA 110 VAKMVQQCCT 120 YVEEITDLPI 130 KLRLIDTLRM 140 VTEGKIYVEI 150 ERARLTKTLA 160 TIKEQNGDVK 170 EAASILQELQ 180 VETYGSMEKK 190 ERVEFILEQM 200 RLCLAVKDYI 210 RTQIISKKIN 220 TKFFQEENTE 230 KLKLKYYNLM 240 IQLDQHEGSY 250 LSICKHYRAI 260 YDTPCIQAES 270 EKWQQALKSV 280 VLYVILAPFD 290 NEQSDLVHRI 300 SGDKKLEEIP 310 KYKDLLKLFT 320 TMELMRWSTL 330 VEDYGMELRK 340 GSLESPATDV 350 FGSTEEGEKR 360 WKDLKNRVVE 370 HNIRIMAKYY 380 TRITMKRMAQ 390 LLDLSVDESE 400 AFLSNLVVNK 410 TIFAKVDRLA 420 GIINFQRPKD 430 PNNLLNDWSQ 440 KLNSLMSLVN 450 KTTHLIAKEE MIHNLQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:1904813 ficolin-1-rich granule lumen
Cellular Component GO:0016020 membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0022624 proteasome accessory complex
Cellular Component GO:0000502 proteasome complex
Cellular Component GO:0005838 proteasome regulatory particle
Cellular Component GO:0008541 proteasome regulatory particle, lid subcomplex
Cellular Component GO:0034774 secretory granule lumen
Cellular Component GO:0008021 synaptic vesicle
Biological Process GO:0071357 cellular response to type I interferon
Biological Process GO:0010498 proteasomal protein catabolic process
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0061136 regulation of proteasomal protein catabolic process
Biological Process GO:0006979 response to oxidative stress

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.