Search Results
Overview
| Uniprot ID | O00241 |
|---|---|
| Protein Name | Signal-regulatory protein beta-1 |
| Gene Name | SIRPB1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 97 | TTVSELTKRNNLDFS |
Function
Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Also participates in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP (PubMed:10604985)
Protein Sequence
10
MPVPASWPHL
20
PSPFLLMTLL
30
LGRLTGVAGE
40
DELQVIQPEK
50
SVSVAAGESA
60
TLRCAMTSLI
70
PVGPIMWFRG
80
AGAGRELIYN
90
QKEGHFPRVT
100
TVSELTKRNN
110
LDFSISISNI
120
TPADAGTYYC
130
VKFRKGSPDD
140
VEFKSGAGTE
150
LSVRAKPSAP
160
VVSGPAVRAT
170
PEHTVSFTCE
180
SHGFSPRDIT
190
LKWFKNGNEL
200
SDFQTNVDPA
210
GDSVSYSIHS
220
TARVVLTRGD
230
VHSQVICEIA
240
HITLQGDPLR
250
GTANLSEAIR
260
VPPTLEVTQQ
270
PMRAENQANV
280
TCQVSNFYPR
290
GLQLTWLENG
300
NVSRTETAST
310
LIENKDGTYN
320
WMSWLLVNTC
330
AHRDDVVLTC
340
QVEHDGQQAV
350
SKSYALEISA
360
HQKEHGSDIT
370
HEAALAPTAP
380
LLVALLLGPK
390
LLLVVGVSAI
YICWKQKA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0030667 | secretory granule membrane |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0050766 | positive regulation of phagocytosis |
| Biological Process | GO:0050870 | positive regulation of T cell activation |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.