Search Results
Overview
| Uniprot ID | O00244 |
|---|---|
| Protein Name | Copper transport protein ATOX1 |
| Gene Name | ATOX1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 25 | AVSRVLNKLGGVKYD |
| 3 | *****MPKHEFSVDM |
| 38 | YDIDLPNKKVCIESE |
| 57 | TLLATLKKTGKTVSY |
| 60 | ATLKKTGKTVSYLGL |
Function
Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0016531 | copper chaperone activity |
| Molecular Function | GO:0005507 | copper ion binding |
| Molecular Function | GO:0032767 | copper-dependent protein binding |
| Molecular Function | GO:1903136 | cuprous ion binding |
| Molecular Function | GO:0016530 | metallochaperone activity |
| Biological Process | GO:0060003 | copper ion export |
| Biological Process | GO:0006825 | copper ion transport |
| Biological Process | GO:0006878 | intracellular copper ion homeostasis |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0006979 | response to oxidative stress |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[3] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.
[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.