Search Results
Overview
| Uniprot ID | O00255 |
|---|---|
| Protein Name | Menin |
| Gene Name | MEN1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 502 | PKKPALDKGLGTGQG |
Function
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair
Protein Sequence
10
MGLKAAQKTL
20
FPLRSIDDVV
30
RLFAAELGRE
40
EPDLVLLSLV
50
LGFVEHFLAV
60
NRVIPTNVPE
70
LTFQPSPAPD
80
PPGGLTYFPV
90
ADLSIIAALY
100
ARFTAQIRGA
110
VDLSLYPREG
120
GVSSRELVKK
130
VSDVIWNSLS
140
RSYFKDRAHI
150
QSLFSFITGT
160
KLDSSGVAFA
170
VVGACQALGL
180
RDVHLALSED
190
HAWVVFGPNG
200
EQTAEVTWHG
210
KGNEDRRGQT
220
VNAGVAERSW
230
LYLKGSYMRC
240
DRKMEVAFMV
250
CAINPSIDLH
260
TDSLELLQLQ
270
QKLLWLLYDL
280
GHLERYPMAL
290
GNLADLEELE
300
PTPGRPDPLT
310
LYHKGIASAK
320
TYYRDEHIYP
330
YMYLAGYHCR
340
NRNVREALQA
350
WADTATVIQD
360
YNYCREDEEI
370
YKEFFEVAND
380
VIPNLLKEAA
390
SLLEAGEERP
400
GEQSQGTQSQ
410
GSALQDPECF
420
AHLLRFYDGI
430
CKWEEGSPTP
440
VLHVGWATFL
450
VQSLGRFEGQ
460
VRQKVRIVSR
470
EAEAAEAEEP
480
WGEEAREGRR
490
RGPRRESKPE
500
EPPPPKKPAL
510
DKGLGTGQGA
520
VSGPPRKPPG
530
TVAGTARGPE
540
GGSTAQVPAP
550
TASPPPEGPV
560
LTFQSEKMKG
570
MKELLVATKI
580
NSSAIKLQLT
590
AQSQVQMKKQ
600
KVSTPSDYTL
610
SFLKRQRKGL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0035097 | histone methyltransferase complex |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0003690 | double-stranded DNA binding |
| Molecular Function | GO:0000400 | four-way junction DNA binding |
| Molecular Function | GO:0051219 | phosphoprotein binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0070412 | R-SMAD binding |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Molecular Function | GO:0000403 | Y-form DNA binding |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0045786 | negative regulation of cell cycle |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0046329 | negative regulation of JNK cascade |
| Biological Process | GO:0045668 | negative regulation of osteoblast differentiation |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0002076 | osteoblast development |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0010332 | response to gamma radiation |
| Biological Process | GO:0009411 | response to UV |
| Biological Process | GO:0045064 | T-helper 2 cell differentiation |
| Biological Process | GO:0045815 | transcription initiation-coupled chromatin remodeling |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0000781 | chromosome, telomeric region |
| Cellular Component | GO:0032154 | cleavage furrow |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
Reference
PMID: N/A