Search Results

Overview

Uniprot IDO00273
Protein NameDNA fragmentation factor subunit alpha
Gene NameDFFA
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
208 KEGSLLSKQEESKAA
313 LRSISASKASPPGDL
324 PGDLQNPKRARQDPT
45 CLEDLRSKACDILAI

Function

Inhibitor of the caspase-activated DNase (DFF40)

Protein Sequence

10 MEVTGDAGVP 20 ESGEIRTLKP 30 CLLRRNYSRE 40 QHGVAASCLE 50 DLRSKACDIL 60 AIDKSLTPVT 70 LVLAEDGTIV 80 DDDDYFLCLP 90 SNTKFVALAS 100 NEKWAYNNSD 110 GGTAWISQES 120 FDVDETDSGA 130 GLKWKNVARQ 140 LKEDLSSIIL 150 LSEEDLQMLV 160 DAPCSDLAQE 170 LRQSCATVQR 180 LQHTLQQVLD 190 QREEVRQSKQ 200 LLQLYLQALE 210 KEGSLLSKQE 220 ESKAAFGEEV 230 DAVDTGISRE 240 TSSDVALASH 250 ILTALREKQA 260 PELSLSSQDL 270 ELVTKEDPKA 280 LAVALNWDIK 290 KTETVQEACE 300 RELALRLQQT 310 QSLHSLRSIS 320 ASKASPPGDL 330 QNPKRARQDP T

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0060703 deoxyribonuclease inhibitor activity
Biological Process GO:0006309 apoptotic DNA fragmentation
Biological Process GO:0006915 apoptotic process
Biological Process GO:1902511 negative regulation of apoptotic DNA fragmentation
Biological Process GO:1900118 negative regulation of execution phase of apoptosis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[6] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[7] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[8] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.