Search Results
Overview
| Uniprot ID | O00330 |
|---|---|
| Protein Name | Pyruvate dehydrogenase protein X component, mitochondrial |
| Gene Name | PDHX |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 120 | IVVEEGSKNIRLGSL |
| 145 | WKHVEIPKDVGPPPP |
| 155 | GPPPPVSKPSEPRPS |
| 172 | PQISIPVKKEHIPGT |
| 194 | AARNILEKHSLDASQ |
| 218 | FTKEDALKLVQLKQT |
| 491 | TRFLKSFKANLENPI |
Function
Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex
Protein Sequence
10
MAASWRLGCD
20
PRLLRYLVGF
30
PGRRSVGLVK
40
GALGWSVSRG
50
ANWRWFHSTQ
60
WLRGDPIKIL
70
MPSLSPTMEE
80
GNIVKWLKKE
90
GEAVSAGDAL
100
CEIETDKAVV
110
TLDASDDGIL
120
AKIVVEEGSK
130
NIRLGSLIGL
140
IVEEGEDWKH
150
VEIPKDVGPP
160
PPVSKPSEPR
170
PSPEPQISIP
180
VKKEHIPGTL
190
RFRLSPAARN
200
ILEKHSLDAS
210
QGTATGPRGI
220
FTKEDALKLV
230
QLKQTGKITE
240
SRPTPAPTAT
250
PTAPSPLQAT
260
AGPSYPRPVI
270
PPVSTPGQPN
280
AVGTFTEIPA
290
SNIRRVIAKR
300
LTESKSTVPH
310
AYATADCDLG
320
AVLKVRQDLV
330
KDDIKVSVND
340
FIIKAAAVTL
350
KQMPDVNVSW
360
DGEGPKQLPF
370
IDISVAVATD
380
KGLLTPIIKD
390
AAAKGIQEIA
400
DSVKALSKKA
410
RDGKLLPEEY
420
QGGSFSISNL
430
GMFGIDEFTA
440
VINPPQACIL
450
AVGRFRPVLK
460
LTEDEEGNAK
470
LQQRQLITVT
480
MSSDSRVVDD
490
ELATRFLKSF
500
KANLENPIRL
A
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045254 | pyruvate dehydrogenase complex |
| Molecular Function | GO:0004742 | dihydrolipoyllysine-residue acetyltransferase activity |
| Biological Process | GO:0006086 | pyruvate decarboxylation to acetyl-CoA |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.