Overview
| Uniprot ID | O00338 |
|---|
| Protein Name | Sulfotransferase 1C2 |
|---|
| Gene Name | SULT1C2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 246 |
TNRSTVSKSILDQSI |
| 9 |
ALTSDLGKQIKLKEV |
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the sulfate conjugation of phenolic compounds (PubMed:10481272, PubMed:10783263, PubMed:9852044). Does not transfer sulfate to steroids, dopamine, acetaminophen, or alpha-naphthol (PubMed:10481272, PubMed:9852044). Except in mitochondria, where it can add sulfate to cholesterol producing cholesterol sulfate, which alters mitochondrial membrane organization, and impacts protein complex mobility increasing state-III respiration, thereby modulating mitochondrial respiration (By similarity). Catalyzes the sulfation of the carcinogenic N-hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:9852044)
Protein Sequence
10
MALTSDLGKQ
20
IKLKEVEGTL
30
LQPATVDNWS
40
QIQSFEAKPD
50
DLLICTYPKA
60
GTTWIQEIVD
70
MIEQNGDVEK
80
CQRAIIQHRH
90
PFIEWARPPQ
100
PSGVEKAKAM
110
PSPRILKTHL
120
STQLLPPSFW
130
ENNCKFLYVA
140
RNAKDCMVSY
150
YHFQRMNHML
160
PDPGTWEEYF
170
ETFINGKVVW
180
GSWFDHVKGW
190
WEMKDRHQIL
200
FLFYEDIKRD
210
PKHEIRKVMQ
220
FMGKKVDETV
230
LDKIVQETSF
240
EKMKENPMTN
250
RSTVSKSILD
260
QSISSFMRKG
270
TVGDWKNHFT
280
VAQNERFDEI
290
YRRKMEGTSI
NFCMEL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005764 |
lysosome |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0004062 |
aryl sulfotransferase activity |
| Molecular Function |
GO:0051922 |
cholesterol sulfotransferase activity |
| Molecular Function |
GO:0008146 |
sulfotransferase activity |
| Biological Process |
GO:0009308 |
amine metabolic process |
| Biological Process |
GO:0051923 |
sulfation |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.