Search Results
Overview
| Uniprot ID | O00391 |
|---|---|
| Protein Name | Sulfhydryl oxidase 1 |
| Gene Name | QSOX1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 172 | CPPLEPAKLEEIDGF |
Function
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:23867277, PubMed:30367560). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:22801504, PubMed:23867277, PubMed:30367560). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:23867277, PubMed:30367560)
Protein Sequence
10
MRRCNSGSGP
20
PPSLLLLLLW
30
LLAVPGANAA
40
PRSALYSPSD
50
PLTLLQADTV
60
RGAVLGSRSA
70
WAVEFFASWC
80
GHCIAFAPTW
90
KALAEDVKAW
100
RPALYLAALD
110
CAEETNSAVC
120
RDFNIPGFPT
130
VRFFKAFTKN
140
GSGAVFPVAG
150
ADVQTLRERL
160
IDALESHHDT
170
WPPACPPLEP
180
AKLEEIDGFF
190
ARNNEEYLAL
200
IFEKGGSYLG
210
REVALDLSQH
220
KGVAVRRVLN
230
TEANVVRKFG
240
VTDFPSCYLL
250
FRNGSVSRVP
260
VLMESRSFYT
270
AYLQRLSGLT
280
REAAQTTVAP
290
TTANKIAPTV
300
WKLADRSKIY
310
MADLESALHY
320
ILRIEVGRFP
330
VLEGQRLVAL
340
KKFVAVLAKY
350
FPGRPLVQNF
360
LHSVNEWLKR
370
QKRNKIPYSF
380
FKTALDDRKE
390
GAVLAKKVNW
400
IGCQGSEPHF
410
RGFPCSLWVL
420
FHFLTVQAAR
430
QNVDHSQEAA
440
KAKEVLPAIR
450
GYVHYFFGCR
460
DCASHFEQMA
470
AASMHRVGSP
480
NAAVLWLWSS
490
HNRVNARLAG
500
APSEDPQFPK
510
VQWPPRELCS
520
ACHNERLDVP
530
VWDVEATLNF
540
LKAHFSPSNI
550
ILDFPAAGSA
560
ARRDVQNVAA
570
APELAMGALE
580
LESRNSTLDP
590
GKPEMMKSPT
600
NTTPHVPAEG
610
PEASRPPKLH
620
PGLRAAPGQE
630
PPEHMAELQR
640
NEQEQPLGQW
650
HLSKRDTGAA
660
LLAESRAEKN
670
RLWGPLEVRR
680
VGRSSKQLVD
690
IPEGQLEARA
700
GRGRGQWLQV
710
LGGGFSYLDI
720
SLCVGLYSLS
730
FMGLLAMYTY
740
FQAKIRALKG
HAGHPAA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0031093 | platelet alpha granule lumen |
| Cellular Component | GO:0035580 | specific granule lumen |
| Cellular Component | GO:1904724 | tertiary granule lumen |
| Molecular Function | GO:0071949 | FAD binding |
| Molecular Function | GO:0016971 | flavin-dependent sulfhydryl oxidase activity |
| Molecular Function | GO:0003756 | protein disulfide isomerase activity |
| Biological Process | GO:0085029 | extracellular matrix assembly |
| Biological Process | GO:0016242 | negative regulation of macroautophagy |
| Biological Process | GO:0006457 | protein folding |
Reference
PMID: N/A