Search Results
Overview
| Uniprot ID | O00399 |
|---|---|
| Protein Name | Dynactin subunit 6 |
| Gene Name | DCTN6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 182 | HHLKKTMKGSSTPVK |
Function
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules
Protein Sequence
10
MAEKTQKSVK
20
IAPGAVVCVE
30
SEIRGDVTIG
40
PRTVIHPKAR
50
IIAEAGPIVI
60
GEGNLIEEQA
70
LIINAYPDNI
80
TPDTEDPEPK
90
PMIIGTNNVF
100
EVGCYSQAMK
110
MGDNNVIESK
120
AYVGRNVILT
130
SGCIIGACCN
140
LNTFEVIPEN
150
TVIYGADCLR
160
RVQTERPQPQ
170
TLQLDFLMKI
180
LPNYHHLKKT
190
MKGSSTPVKN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005869 | dynactin complex |
| Cellular Component | GO:0000776 | kinetochore |
| Molecular Function | GO:0070840 | dynein complex binding |
| Biological Process | GO:0007052 | mitotic spindle organization |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.