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Overview

Uniprot IDO00410
Protein NameImportin-5
Gene NameIPO5
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
108 TQSSMRKKVCDIAAE
800 LGGILKAKLEEHFKN

Function

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607, PubMed:9687515). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev

Protein Sequence

10 MAAAAAEQQQ 20 FYLLLGNLLS 30 PDNVVRKQAE 40 ETYENIPGQS 50 KITFLLQAIR 60 NTTAAEEARQ 70 MAAVLLRRLL 80 SSAFDEVYPA 90 LPSDVQTAIK 100 SELLMIIQME 110 TQSSMRKKVC 120 DIAAELARNL 130 IDEDGNNQWP 140 EGLKFLFDSV 150 SSQNVGLREA 160 ALHIFWNFPG 170 IFGNQQQHYL 180 DVIKRMLVQC 190 MQDQEHPSIR 200 TLSARATAAF 210 ILANEHNVAL 220 FKHFADLLPG 230 FLQAVNDSCY 240 QNDDSVLKSL 250 VEIADTVPKY 260 LRPHLEATLQ 270 LSLKLCGDTS 280 LNNMQRQLAL 290 EVIVTLSETA 300 AAMLRKHTNI 310 VAQTIPQMLA 320 MMVDLEEDED 330 WANADELEDD 340 DFDSNAVAGE 350 SALDRMACGL 360 GGKLVLPMIK 370 EHIMQMLQNP 380 DWKYRHAGLM 390 ALSAIGEGCH 400 QQMEGILNEI 410 VNFVLLFLQD 420 PHPRVRYAAC 430 NAVGQMATDF 440 APGFQKKFHE 450 KVIAALLQTM 460 EDQGNQRVQA 470 HAAAALINFT 480 EDCPKSLLIP 490 YLDNLVKHLH 500 SIMVLKLQEL 510 IQKGTKLVLE 520 QVVTSIASVA 530 DTAEEKFVPY 540 YDLFMPSLKH 550 IVENAVQKEL 560 RLLRGKTIEC 570 ISLIGLAVGK 580 EKFMQDASDV 590 MQLLLKTQTD 600 FNDMEDDDPQ 610 ISYMISAWAR 620 MCKILGKEFQ 630 QYLPVVMGPL 640 MKTASIKPEV 650 ALLDTQDMEN 660 MSDDDGWEFV 670 NLGDQQSFGI 680 KTAGLEEKST 690 ACQMLVCYAK 700 ELKEGFVEYT 710 EQVVKLMVPL 720 LKFYFHDGVR 730 VAAAESMPLL 740 LECARVRGPE 750 YLTQMWHFMC 760 DALIKAIGTE 770 PDSDVLSEIM 780 HSFAKCIEVM 790 GDGCLNNEHF 800 EELGGILKAK 810 LEEHFKNQEL 820 RQVKRQDEDY 830 DEQVEESLQD 840 EDDNDVYILT 850 KVSDILHSIF 860 SSYKEKVLPW 870 FEQLLPLIVN 880 LICPHRPWPD 890 RQWGLCIFDD 900 VIEHCSPASF 910 KYAEYFLRPM 920 LQYVCDNSPE 930 VRQAAAYGLG 940 VMAQYGGDNY 950 RPFCTEALPL 960 LVRVIQSADS 970 KTKENVNATE 980 NCISAVGKIM 990 KFKPDCVNVE 1000 EVLPHWLSWL 1010 PLHEDKEEAV 1020 QTFNYLCDLI 1030 ESNHPIVLGP 1040 NNTNLPKIFS 1050 IIAEGEMHEA 1060 IKHEDPCAKR 1070 LANVVRQVQT 1080 SGGLWTECIA 1090 QLSPEQQAAI QELLNSA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005643 nuclear pore
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005095 GTPase inhibitor activity
Molecular Function GO:0061608 nuclear import signal receptor activity
Molecular Function GO:0008139 nuclear localization sequence binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0071230 cellular response to amino acid stimulus
Biological Process GO:0002753 cytoplasmic pattern recognition receptor signaling pathway
Biological Process GO:0045786 negative regulation of cell cycle
Biological Process GO:0006607 NLS-bearing protein import into nucleus
Biological Process GO:0042307 positive regulation of protein import into nucleus
Biological Process GO:0006606 protein import into nucleus
Biological Process GO:0006610 ribosomal protein import into nucleus

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.