Search Results
Overview
| Uniprot ID | O00418 |
|---|---|
| Protein Name | Eukaryotic elongation factor 2 kinase |
| Gene Name | EEF2K |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 65 | KYYSNLTKSERYSSS |
Function
Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced
Protein Sequence
10
MADEDLIFRL
20
EGVDGGQSPR
30
AGHDGDSDGD
40
SDDEEGYFIC
50
PITDDPSSNQ
60
NVNSKVNKYY
70
SNLTKSERYS
80
SSGSPANSFH
90
FKEAWKHAIQ
100
KAKHMPDPWA
110
EFHLEDIATE
120
RATRHRYNAV
130
TGEWLDDEVL
140
IKMASQPFGR
150
GAMRECFRTK
160
KLSNFLHAQQ
170
WKGASNYVAK
180
RYIEPVDRDV
190
YFEDVRLQME
200
AKLWGEEYNR
210
HKPPKQVDIM
220
QMCIIELKDR
230
PGKPLFHLEH
240
YIEGKYIKYN
250
SNSGFVRDDN
260
IRLTPQAFSH
270
FTFERSGHQL
280
IVVDIQGVGD
290
LYTDPQIHTE
300
TGTDFGDGNL
310
GVRGMALFFY
320
SHACNRICES
330
MGLAPFDLSP
340
RERDAVNQNT
350
KLLQSAKTIL
360
RGTEEKCGSP
370
QVRTLSGSRP
380
PLLRPLSENS
390
GDENMSDVTF
400
DSLPSSPSSA
410
TPHSQKLDHL
420
HWPVFSDLDN
430
MASRDHDHLD
440
NHRESENSGD
450
SGYPSEKRGE
460
LDDPEPREHG
470
HSYSNRKYES
480
DEDSLGSSGR
490
VCVEKWNLLN
500
SSRLHLPRAS
510
AVALEVQRLN
520
ALDLEKKIGK
530
SILGKVHLAM
540
VRYHEGGRFC
550
EKGEEWDQES
560
AVFHLEHAAN
570
LGELEAIVGL
580
GLMYSQLPHH
590
ILADVSLKET
600
EENKTKGFDY
610
LLKAAEAGDR
620
QSMILVARAF
630
DSGQNLSPDR
640
CQDWLEALHW
650
YNTALEMTDC
660
DEGGEYDGMQ
670
DEPRYMMLAR
680
EAEMLFTGGY
690
GLEKDPQRSG
700
DLYTQAAEAA
710
MEAMKGRLAN
720
QYYQKAEEAW
AQMEE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0014069 | postsynaptic density |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0004686 | elongation factor-2 kinase activity |
| Molecular Function | GO:0004672 | protein kinase activity |
| Molecular Function | GO:0008135 | translation factor activity, RNA binding |
| Biological Process | GO:0071454 | cellular response to anoxia |
| Biological Process | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus |
| Biological Process | GO:0071277 | cellular response to calcium ion |
| Biological Process | GO:0071320 | cellular response to cAMP |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0061003 | positive regulation of dendritic spine morphogenesis |
| Biological Process | GO:0045807 | positive regulation of endocytosis |
| Biological Process | GO:0051965 | positive regulation of synapse assembly |
| Biological Process | GO:0046777 | protein autophosphorylation |
| Biological Process | GO:0140245 | regulation of translation at postsynapse |
| Biological Process | GO:0002931 | response to ischemia |
| Biological Process | GO:1990637 | response to prolactin |
| Biological Process | GO:0006414 | translational elongation |
Reference
PMID: N/A