Overview
| Uniprot ID | O00422 |
|---|
| Protein Name | Histone deacetylase complex subunit SAP18 |
|---|
| Gene Name | SAP18 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 14 |
VTQEEIKKEPEKPID |
Function
Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function
Protein Sequence
10
MAVESRVTQE
20
EIKKEPEKPI
30
DREKTCPLLL
40
RVFTTNNGRH
50
HRMDEFSRGN
60
VPSSELQIYT
70
WMDATLKELT
80
SLVKEVYPEA
90
RKKGTHFNFA
100
IVFTDVKRPG
110
YRVKEIGSTM
120
SGRKGTDDSM
130
TLQSQKFQIG
140
DYLDIAITPP
150
NRAPPPSGRM
RPY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0061574 |
ASAP complex |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0000118 |
histone deacetylase complex |
| Cellular Component |
GO:0016604 |
nuclear body |
| Cellular Component |
GO:0016607 |
nuclear speck |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0003714 |
transcription corepressor activity |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0045892 |
negative regulation of DNA-templated transcription |
| Biological Process |
GO:0048025 |
negative regulation of mRNA splicing, via spliceosome |
| Biological Process |
GO:0043065 |
positive regulation of apoptotic process |
| Biological Process |
GO:0000381 |
regulation of alternative mRNA splicing, via spliceosome |
| Biological Process |
GO:0050684 |
regulation of mRNA processing |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
[1] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.