Search Results
Overview
| Uniprot ID | O00423 |
|---|---|
| Protein Name | Echinoderm microtubule-associated protein-like 1 |
| Gene Name | EML1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 79 | QQAVLNRKGPTKARP |
Function
Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se
Protein Sequence
10
MEDGFSSYSS
20
LYDTSSLLQF
30
CNDDSASAAS
40
SMEVTDRIAS
50
LEQRVQMQED
60
DIQLLKSALA
70
DVVRRLNITE
80
EQQAVLNRKG
90
PTKARPLMQT
100
LPLRTTVNNG
110
TVLPKKPTGS
120
LPSPSGVRKE
130
TAVPATKSNI
140
KRTSSSERVS
150
PGGRRESNGD
160
SRGNRNRTGS
170
TSSSSSGKKN
180
SESKPKEPVF
190
SAEEGYVKMF
200
LRGRPVTMYM
210
PKDQVDSYSL
220
EAKVELPTKR
230
LKLEWVYGYR
240
GRDCRNNLYL
250
LPTGETVYFI
260
ASVVVLYNVE
270
EQLQRHYAGH
280
NDDVKCLAVH
290
PDRITIATGQ
300
VAGTSKDGKQ
310
LPPHVRIWDS
320
VTLNTLHVIG
330
IGFFDRAVTC
340
IAFSKSNGGT
350
NLCAVDDSND
360
HVLSVWDWQK
370
EEKLADVKCS
380
NEAVFAADFH
390
PTDTNIIVTC
400
GKSHLYFWTL
410
EGSSLNKKQG
420
LFEKQEKPKF
430
VLCVTFSENG
440
DTITGDSSGN
450
ILVWGKGTNR
460
ISYAVQGAHE
470
GGIFALCMLR
480
DGTLVSGGGK
490
DRKLISWSGN
500
YQKLRKTEIP
510
EQFGPIRTVA
520
EGKGDVILIG
530
TTRNFVLQGT
540
LSGDFTPITQ
550
GHTDELWGLA
560
IHASKSQFLT
570
CGHDKHATLW
580
DAVGHRPVWD
590
KIIEDPAQSS
600
GFHPSGSVVA
610
VGTLTGRWFV
620
FDTETKDLVT
630
VHTDGNEQLS
640
VMRYSPDGNF
650
LAIGSHDNCI
660
YIYGVSDNGR
670
KYTRVGKCSG
680
HSSFITHLDW
690
SVNSQFLVSN
700
SGDYEILYWV
710
PSACKQVVSV
720
ETTRDIEWAT
730
YTCTLGFHVF
740
GVWPEGSDGT
750
DINAVCRAHE
760
KKLLSTGDDF
770
GKVHLFSYPC
780
SQFRAPSHIY
790
GGHSSHVTNV
800
DFLCEDSHLI
810
STGGKDTSIM
QWRVI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0005875 | microtubule associated complex |
| Cellular Component | GO:1990023 | mitotic spindle midzone |
| Cellular Component | GO:0097431 | mitotic spindle pole |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0015631 | tubulin binding |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0007052 | mitotic spindle organization |
| Biological Process | GO:0007405 | neuroblast proliferation |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.