Search Results
Overview
| Uniprot ID | O00445 |
|---|---|
| Protein Name | Synaptotagmin-5 |
| Gene Name | SYT5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 239 | APREEQEKLGDICFS |
Function
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity)
Protein Sequence
10
MFPEPPTPGP
20
PSPDTPPDSS
30
RISHGPVPPW
40
ALATIVLVSG
50
LLIFSCCFCL
60
YRKSCRRRTG
70
KKSQAQAQVH
80
LQEVKGLGQS
90
YIDKVQPEVE
100
ELEPAPSGPG
110
QQVADKHELG
120
RLQYSLDYDF
130
QSGQLLVGIL
140
QAMGLAALDL
150
GGSSDPYVRV
160
YLLPDKRRRY
170
ETKVHRQTLN
180
PHFGETFAFK
190
VPYVELGGRV
200
LVMAVYDFDR
210
FSRNDAIGEV
220
RVPMSSVDLG
230
RPVQAWRELQ
240
AAPREEQEKL
250
GDICFSLRYV
260
PTAGKLTVIV
270
LEAKNLKKMD
280
VGGLSDPYVK
290
VHLLQGGKKV
300
RKKKTTIKKN
310
TLNPYYNEAF
320
SFEVPCDQVQ
330
KVQVELTVLD
340
YDKLGKNEAI
350
GRVAVGAAAG
360
GAGLRHWADM
370
LANPRRPIAQ
380
WHSLRPPDRV
RLLPAP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0016192 | vesicle-mediated transport |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0031045 | dense core granule |
| Cellular Component | GO:0070382 | exocytic vesicle |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0099012 | neuronal dense core vesicle membrane |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:1990769 | proximal neuron projection |
| Cellular Component | GO:0055038 | recycling endosome membrane |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0061891 | calcium ion sensor activity |
| Molecular Function | GO:0005544 | calcium-dependent phospholipid binding |
| Molecular Function | GO:0030276 | clathrin binding |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function | GO:0001786 | phosphatidylserine binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0000149 | SNARE binding |
| Molecular Function | GO:0019905 | syntaxin binding |
| Biological Process | GO:0099502 | calcium-dependent activation of synaptic vesicle fusion |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0017158 | regulation of calcium ion-dependent exocytosis |
| Biological Process | GO:2000300 | regulation of synaptic vesicle exocytosis |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.