Search Results
Overview
| Uniprot ID | O00469 |
|---|---|
| Protein Name | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 |
| Gene Name | PLOD2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 335 | LKLFIHNKEVYHEKD |
| 89 | NSIGGGQKVRLMKEV |
Function
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links
Protein Sequence
10
MGGCTVKPQL
20
LLLALVLHPW
30
NPCLGADSEK
40
PSSIPTDKLL
50
VITVATKESD
60
GFHRFMQSAK
70
YFNYTVKVLG
80
QGEEWRGGDG
90
INSIGGGQKV
100
RLMKEVMEHY
110
ADQDDLVVMF
120
TECFDVIFAG
130
GPEEVLKKFQ
140
KANHKVVFAA
150
DGILWPDKRL
160
ADKYPVVHIG
170
KRYLNSGGFI
180
GYAPYVNRIV
190
QQWNLQDNDD
200
DQLFYTKVYI
210
DPLKREAINI
220
TLDHKCKIFQ
230
TLNGAVDEVV
240
LKFENGKARA
250
KNTFYETLPV
260
AINGNGPTKI
270
LLNYFGNYVP
280
NSWTQDNGCT
290
LCEFDTVDLS
300
AVDVHPNVSI
310
GVFIEQPTPF
320
LPRFLDILLT
330
LDYPKEALKL
340
FIHNKEVYHE
350
KDIKVFFDKA
360
KHEIKTIKIV
370
GPEENLSQAE
380
ARNMGMDFCR
390
QDEKCDYYFS
400
VDADVVLTNP
410
RTLKILIEQN
420
RKIIAPLVTR
430
HGKLWSNFWG
440
ALSPDGYYAR
450
SEDYVDIVQG
460
NRVGVWNVPY
470
MANVYLIKGK
480
TLRSEMNERN
490
YFVRDKLDPD
500
MALCRNAREM
510
GVFMYISNRH
520
EFGRLLSTAN
530
YNTSHYNNDL
540
WQIFENPVDW
550
KEKYINRDYS
560
KIFTENIVEQ
570
PCPDVFWFPI
580
FSEKACDELV
590
EEMEHYGKWS
600
GGKHHDSRIS
610
GGYENVPTDD
620
IHMKQVDLEN
630
VWLHFIREFI
640
APVTLKVFAG
650
YYTKGFALLN
660
FVVKYSPERQ
670
RSLRPHHDAS
680
TFTINIALNN
690
VGEDFQGGGC
700
KFLRYNCSIE
710
SPRKGWSFMH
720
PGRLTHLHEG
730
LPVKNGTRYI
AVSFIDP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0030867 | rough endoplasmic reticulum membrane |
| Molecular Function | GO:0005506 | iron ion binding |
| Molecular Function | GO:0031418 | L-ascorbic acid binding |
| Molecular Function | GO:0008475 | procollagen-lysine 5-dioxygenase activity |
| Biological Process | GO:0032964 | collagen biosynthetic process |
| Biological Process | GO:0030199 | collagen fibril organization |
| Biological Process | GO:0046947 | hydroxylysine biosynthetic process |
| Biological Process | GO:0001666 | response to hypoxia |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.