Search Results
Overview
| Uniprot ID | O00515 |
|---|---|
| Protein Name | Ladinin-1 |
| Gene Name | LAD1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 199 | EKSLVSDKTSISEKV |
| 205 | DKTSISEKVLASEKT |
| 211 | EKVLASEKTSLSEKI |
| 235 | EKKSVLEKTSVSEKS |
| 259 | GRRLVSEKASIFEKA |
| 265 | EKASIFEKALASEKS |
| 316 | RGRALPGKNLPSLAK |
| 323 | KNLPSLAKQGASDPP |
| 382 | SFRMKPKKENSETTL |
| 6 | **MAVSRKDWSALSS |
Function
Anchoring filament protein which is a component of the basement membrane zone
Protein Sequence
10
MAVSRKDWSA
20
LSSLARQRTL
30
EDEEEQERER
40
RRRHRNLSST
50
TDDEAPRLSQ
60
NGDRQASASE
70
RLPSVEEAEV
80
PKPLPPASKD
90
EDEDIQSILR
100
TRQERRQRRQ
110
VVEAAQAPIQ
120
ERLEAEEGRN
130
SLSPVQATQK
140
PLVSKKELEI
150
PPRRRLSREQ
160
RGPWALEEES
170
LVGREPEERK
180
KGVPEKSPVL
190
EKSSMPKKTA
200
PEKSLVSDKT
210
SISEKVLASE
220
KTSLSEKIAV
230
SEKRNSSEKK
240
SVLEKTSVSE
250
KSLAPGMALG
260
SGRRLVSEKA
270
SIFEKALASE
280
KSPTADAKPA
290
PKRATASEQP
300
LAQEPPASGG
310
SPATTKEQRG
320
RALPGKNLPS
330
LAKQGASDPP
340
TVASRLPPVT
350
LQVKIPSKEE
360
EADMSSPTQR
370
TYSSSLKRSS
380
PRTISFRMKP
390
KKENSETTLT
400
RSASMKLPDN
410
TVKLGEKLER
420
YHTAIRRSES
430
VKSRGLPCTE
440
LFVAPVGVAS
450
KRHLFEKELA
460
GQSRAEPASS
470
RKENLRLSGV
480
VTSRLNLWIS
490
RTQESGDQDP
500
QEAQKASSAT
510
ERTQWGQKSD
SSLDAEV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005604 | basement membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0005198 | structural molecule activity |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.