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Overview

Uniprot IDO00533
Protein NameNeural cell adhesion molecule L1-like protein
Gene NameCHL1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
726 RVQASQPKEMIIKWE

Function

Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity)

Protein Sequence

10 MEPLLLGRGL 20 IVYLMFLLLK 30 FSKAIEIPSS 40 VQQVPTIIKQ 50 SKVQVAFPFD 60 EYFQIECEAK 70 GNPEPTFSWT 80 KDGNPFYFTD 90 HRIIPSNNSG 100 TFRIPNEGHI 110 SHFQGKYRCF 120 ASNKLGIAMS 130 EEIEFIVPSV 140 PKFPKEKIDP 150 LEVEEGDPIV 160 LPCNPPKGLP 170 PLHIYWMNIE 180 LEHIEQDERV 190 YMSQKGDLYF 200 ANVEEKDSRN 210 DYCCFAAFPR 220 LRTIVQKMPM 230 KLTVNSSNSI 240 KQRKPKLLLP 250 PTESGSESSI 260 TILKGEILLL 270 ECFAEGLPTP 280 QVDWNKIGGD 290 LPKGRETKEN 300 YGKTLKIENV 310 SYQDKGNYRC 320 TASNFLGTAT 330 HDFHVIVEEP 340 PRWTKKPQSA 350 VYSTGSNGIL 360 LCEAEGEPQP 370 TIKWRVNGSP 380 VDNHPFAGDV 390 VFPREISFTN 400 LQPNHTAVYQ 410 CEASNVHGTI 420 LANANIDVVD 430 VRPLIQTKDG 440 ENYATVVGYS 450 AFLHCEFFAS 460 PEAVVSWQKV 470 EEVKPLEGRR 480 YHIYENGTLQ 490 INRTTEEDAG 500 SYSCWVENAI 510 GKTAVTANLD 520 IRNATKLRVS 530 PKNPRIPKLH 540 MLELHCESKC 550 DSHLKHSLKL 560 SWSKDGEAFE 570 INGTEDGRII 580 IDGANLTISN 590 VTLEDQGIYC 600 CSAHTALDSA 610 ADITQVTVLD 620 VPDPPENLHL 630 SERQNRSVRL 640 TWEAGADHNS 650 NISEYIVEFE 660 GNKEEPGRWE 670 ELTRVQGKKT 680 TVILPLAPFV 690 RYQFRVIAVN 700 EVGRSQPSQP 710 SDHHETPPAA 720 PDRNPQNIRV 730 QASQPKEMII 740 KWEPLKSMEQ 750 NGPGLEYRVT 760 WKPQGAPVEW 770 EEETVTNHTL 780 RVMTPAVYAP 790 YDVKVQAINQ 800 LGSGPDPQSV 810 TLYSGEDYPD 820 TAPVIHGVDV 830 INSTLVKVTW 840 STVPKDRVHG 850 RLKGYQINWW 860 KTKSLLDGRT 870 HPKEVNILRF 880 SGQRNSGMVP 890 SLDAFSEFHL 900 TVLAYNSKGA 910 GPESEPYIFQ 920 TPEGVPEQPT 930 FLKVIKVDKD 940 TATLSWGLPK 950 KLNGNLTGYL 960 LQYQIINDTY 970 EIGELNDINI 980 TTPSKPSWHL 990 SNLNATTKYK 1000 FYLRACTSQG 1010 CGKPITEESS 1020 TLGEGSKGIG 1030 KISGVNLTQK 1040 THPIEVFEPG 1050 AEHIVRLMTK 1060 NWGDNDSIFQ 1070 DVIETRGREY 1080 AGLYDDISTQ 1090 GWFIGLMCAI 1100 ALLTLLLLTV 1110 CFVKRNRGGK 1120 YSVKEKEDLH 1130 PDPEIQSVKD 1140 ETFGEYSDSD 1150 EKPLKGSLRS 1160 LNRDMQPTES 1170 ADSLVEYGEG 1180 DHGLFSEDGS 1190 FIGAYAGSKE 1200 KGSVESNGSS TATFPLRA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0045177 apical part of cell
Cellular Component GO:0030425 dendrite
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0002020 protease binding
Biological Process GO:0007155 cell adhesion
Biological Process GO:0030154 cell differentiation
Biological Process GO:0043524 negative regulation of neuron apoptotic process
Biological Process GO:0007399 nervous system development
Biological Process GO:0007165 signal transduction

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.