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Overview

Uniprot IDO00534
Protein Namevon Willebrand factor A domain-containing protein 5A
Gene NameVWA5A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
160 YQFSGSSKDSCLNVK
621 LGASAPLKIKCQSGF
623 ASAPLKIKCQSGFRK
630 KCQSGFRKALHSDRP

Function

May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis

Protein Sequence

10 MVHFCGLLTL 20 HREPVPLKSI 30 SVSVNIYEFV 40 AGVSATLNYE 50 NEEKVPLEAF 60 FVFPMDEDSA 70 VYSFEALVDG 80 KKIVAELQDK 90 MKARTNYEKA 100 ISQGHQAFLL 110 EGDSSSRDVF 120 SCNVGNLQPG 130 SKAAVTLKYV 140 QELPLEADGA 150 LRFVLPAVLN 160 PRYQFSGSSK 170 DSCLNVKTPI 180 VPVEDLPYTL 190 SMVATIDSQH 200 GIEKVQSNCP 210 LSPTEYLGED 220 KTSAQVSLAA 230 GHKFDRDVEL 240 LIYYNEVHTP 250 SVVLEMGMPN 260 MKPGHLMGDP 270 SAMVSFYPNI 280 PEDQPSNTCG 290 EFIFLMDRSG 300 SMQSPMSSQD 310 TSQLRIQAAK 320 ETLILLLKSL 330 PIGCYFNIYG 340 FGSSYEACFP 350 ESVKYTQQTM 360 EEALGRVKLM 370 QADLGGTEIL 380 APLQNIYRGP 390 SIPGHPLQLF 400 VFTDGEVTDT 410 FSVIKEVRIN 420 RQKHRCFSFG 430 IGEGTSTSLI 440 KGIARASGGT 450 SEFITGKDRM 460 QSKALRTLKR 470 SLQPVVEDVS 480 LSWHLPPGLS 490 AKMLSPEQTV 500 IFRGQRLISY 510 AQLTGRMPAA 520 ETTGEVCLKY 530 TLQGKTFEDK 540 VTFPLQPKPD 550 VNLTIHRLAA 560 KSLLQTKDMG 570 LRETPASDKK 580 DALNLSLESG 590 VISSFTAFIA 600 INKELNKPVQ 610 GPLAHRDVPR 620 PILLGASAPL 630 KIKCQSGFRK 640 ALHSDRPPSA 650 SQPRGELMCY 660 KAKTFQMDDY 670 SLCGLISHKD 680 QHSPGFGENH 690 LVQLIYHQNA 700 NGSWDLNEDL 710 AKILGMSLEE 720 IMAAQPAELV 730 DSSGWATILA 740 VIWLHSNGKD 750 LKCEWELLER 760 KAVAWMRAHA 770 GSTMPSVVKA 780 AITFLKSSVD PAIFAF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.