Search Results

Overview

Uniprot IDO00560
Protein NameSyntenin-1
Gene NameSDCBP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
223 GKITSIVKDSSAARN

Function

Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395)

Protein Sequence

10 MSLYPSLEDL 20 KVDKVIQAQT 30 AFSANPANPA 40 ILSEASAPIP 50 HDGNLYPRLY 60 PELSQYMGLS 70 LNEEEIRANV 80 AVVSGAPLQG 90 QLVARPSSIN 100 YMVAPVTGND 110 VGIRRAEIKQ 120 GIREVILCKD 130 QDGKIGLRLK 140 SIDNGIFVQL 150 VQANSPASLV 160 GLRFGDQVLQ 170 INGENCAGWS 180 SDKAHKVLKQ 190 AFGEKITMTI 200 RDRPFERTIT 210 MHKDSTGHVG 220 FIFKNGKITS 230 IVKDSSAARN 240 GLLTEHNICE 250 INGQNVIGLK 260 DSQIADILST 270 SGTVVTITIM 280 PAFIFEHIIK 290 RMAPSIMKSL MDHTIPEV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0035578 azurophil granule lumen
Cellular Component GO:0072562 blood microparticle
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:1903561 extracellular vesicle
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005895 interleukin-5 receptor complex
Cellular Component GO:0042470 melanosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0045202 synapse
Molecular Function GO:0008093 cytoskeletal anchor activity
Molecular Function GO:0005109 frizzled binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0005137 interleukin-5 receptor binding
Molecular Function GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0140311 protein sequestering activity
Molecular Function GO:0045545 syndecan binding
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0007268 chemical synaptic transmission
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0002091 negative regulation of receptor internalization
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0030307 positive regulation of cell growth
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0010718 positive regulation of epithelial to mesenchymal transition
Biological Process GO:1903543 positive regulation of exosomal secretion
Biological Process GO:1903553 positive regulation of extracellular exosome assembly
Biological Process GO:0046330 positive regulation of JNK cascade
Biological Process GO:0042327 positive regulation of phosphorylation
Biological Process GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
Biological Process GO:0006612 protein targeting to membrane
Biological Process GO:0007346 regulation of mitotic cell cycle
Biological Process GO:0006930 substrate-dependent cell migration, cell extension

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.