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Overview

Uniprot IDO00566
Protein NameU3 small nucleolar ribonucleoprotein protein MPP10
Gene NameMPHOSPH10
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
157 ERAENSSKSDLRKSP
185 SKLEQQSKVQNKGQG
612 DQAGKYSKTVASEKL
641 EGKDKALKSSQAFFS
649 SSQAFFSKLQDQVKM
655 SKLQDQVKMQINDAK

Function

Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (PubMed:12655004). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)

Protein Sequence

10 MAPQVWRRRT 20 LERCLTEVGK 30 ATGRPECFLT 40 IQEGLASKFT 50 SLTKVLYDFN 60 KILENGRIHG 70 SPLQKLVIEN 80 FDDEQIWQQL 90 ELQNEPILQY 100 FQNAVSETIN 110 DEDISLLPES 120 EEQEREEDGS 130 EIEADDKEDL 140 EDLEEEEVSD 150 MGNDDPEMGE 160 RAENSSKSDL 170 RKSPVFSDED 180 SDLDFDISKL 190 EQQSKVQNKG 200 QGKPREKSIV 210 DDKFFKLSEM 220 EAYLENIEKE 230 EERKDDNDEE 240 EEDIDFFEDI 250 DSDEDEGGLF 260 GSKKLKSGKS 270 SRNLKYKDFF 280 DPVESDEDIT 290 NVHDDELDSN 300 KEDDEIAEEE 310 AEELSISETD 320 EDDDLQENED 330 NKQHKESLKR 340 VTFALPDDAE 350 TEDTGVLNVK 360 KNSDEVKSSF 370 EKRQEKMNEK 380 IASLEKELLE 390 KKPWQLQGEV 400 TAQKRPENSL 410 LEETLHFDHA 420 VRMAPVITEE 430 TTLQLEDIIK 440 QRIRDQAWDD 450 VVRKEKPKED 460 AYEYKKRLTL 470 DHEKSKLSLA 480 EIYEQEYIKL 490 NQQKTAEEEN 500 PEHVEIQKMM 510 DSLFLKLDAL 520 SNFHFIPKPP 530 VPEIKVVSNL 540 PAITMEEVAP 550 VSVSDAALLA 560 PEEIKEKNKA 570 GDIKTAAEKT 580 ATDKKRERRK 590 KKYQKRMKIK 600 EKEKRRKLLE 610 KSSVDQAGKY 620 SKTVASEKLK 630 QLTKTGKASF 640 IKDEGKDKAL 650 KSSQAFFSKL 660 QDQVKMQIND 670 AKKTEKKKKK 680 RQDISVHKLK L

Gene Ontology

Classification GO ID Description
Biological Process GO:0000375 RNA splicing, via transesterification reactions
Cellular Component GO:0005694 chromosome
Cellular Component GO:0034457 Mpp10 complex
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0032040 small-subunit processome
Cellular Component GO:0005732 sno(s)RNA-containing ribonucleoprotein complex
Molecular Function GO:0003723 RNA binding
Biological Process GO:0030490 maturation of SSU-rRNA
Biological Process GO:0042274 ribosomal small subunit biogenesis
Biological Process GO:0006396 RNA processing
Biological Process GO:0008380 RNA splicing

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.