Search Results
Overview
| Uniprot ID | O00712 |
|---|---|
| Protein Name | Nuclear factor 1 B-type |
| Gene Name | NFIB |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 273 | PPSSKRPKTISIDEN |
Function
Transcriptional activator of GFAP, essential for proper brain development (PubMed:30388402). Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication
Protein Sequence
10
MMYSPICLTQ
20
DEFHPFIEAL
30
LPHVRAIAYT
40
WFNLQARKRK
50
YFKKHEKRMS
60
KDEERAVKDE
70
LLSEKPEIKQ
80
KWASRLLAKL
90
RKDIRQEYRE
100
DFVLTVTGKK
110
HPCCVLSNPD
120
QKGKIRRIDC
130
LRQADKVWRL
140
DLVMVILFKG
150
IPLESTDGER
160
LMKSPHCTNP
170
ALCVQPHHIT
180
VSVKELDLFL
190
AYYVQEQDSG
200
QSGSPSHNDP
210
AKNPPGYLED
220
SFVKSGVFNV
230
SELVRVSRTP
240
ITQGTGVNFP
250
IGEIPSQPYY
260
HDMNSGVNLQ
270
RSLSSPPSSK
280
RPKTISIDEN
290
MEPSPTGDFY
300
PSPSSPAAGS
310
RTWHERDQDM
320
SSPTTMKKPE
330
KPLFSSASPQ
340
DSSPRLSTFP
350
QHHHPGIPGV
360
AHSVISTRTP
370
PPPSPLPFPT
380
QAILPPAPSS
390
YFSHPTIRYP
400
PHLNPQDTLK
410
NYVPSYDPSS
420
PQTSQSWYLG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0044300 | cerebellar mossy fiber |
| Biological Process | GO:0071679 | commissural neuron axon guidance |
| Biological Process | GO:0006260 | DNA replication |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0010001 | glial cell differentiation |
| Biological Process | GO:0061141 | lung ciliated cell differentiation |
| Biological Process | GO:0043392 | negative regulation of DNA binding |
| Biological Process | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis |
| Biological Process | GO:2000791 | negative regulation of mesenchymal cell proliferation involved in lung development |
| Biological Process | GO:1902894 | negative regulation of miRNA transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0021740 | principal sensory nucleus of trigeminal nerve development |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0060509 | type I pneumocyte differentiation |
| Biological Process | GO:0060510 | type II pneumocyte differentiation |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0001650 | fibrillar center |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Molecular Function | GO:0140416 | transcription regulator inhibitor activity |
| Biological Process | GO:0021960 | anterior commissure morphogenesis |
| Biological Process | GO:0007420 | brain development |
| Biological Process | GO:0021846 | cell proliferation in forebrain |
| Biological Process | GO:0002062 | chondrocyte differentiation |
| Biological Process | GO:0060486 | club cell differentiation |
Reference
PMID: N/A