Overview
| Uniprot ID | O00743 |
|---|
| Protein Name | Serine/threonine-protein phosphatase 6 catalytic subunit |
|---|
| Gene Name | PPP6C |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 251 |
YKFMFDEKLVTVWSA |
Function
Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:17079228, PubMed:29053956, PubMed:32474700). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (PubMed:10227379). N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 (PubMed:17568194). During mitosis, regulates spindle positioning (PubMed:27335426). Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (PubMed:17079228). Also participates in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signaling activation (PubMed:29053956). Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1 (PubMed:32474700, PubMed:32753499). CGAS dephosphorylation at 'Ser-435' impairs its ability to bind GTP, thereby inactivating it (PubMed:32474700)
Protein Sequence
10
MAPLDLDKYV
20
EIARLCKYLP
30
ENDLKRLCDY
40
VCDLLLEESN
50
VQPVSTPVTV
60
CGDIHGQFYD
70
LCELFRTGGQ
80
VPDTNYIFMG
90
DFVDRGYYSL
100
ETFTYLLALK
110
AKWPDRITLL
120
RGNHESRQIT
130
QVYGFYDECQ
140
TKYGNANAWR
150
YCTKVFDMLT
160
VAALIDEQIL
170
CVHGGLSPDI
180
KTLDQIRTIE
190
RNQEIPHKGA
200
FCDLVWSDPE
210
DVDTWAISPR
220
GAGWLFGAKV
230
TNEFVHINNL
240
KLICRAHQLV
250
HEGYKFMFDE
260
KLVTVWSAPN
270
YCYRCGNIAS
280
IMVFKDVNTR
290
EPKLFRAVPD
300
SERVIPPRTT
TPYFL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0004722 |
protein serine/threonine phosphatase activity |
| Biological Process |
GO:0048208 |
COPII vesicle coating |
| Biological Process |
GO:0000082 |
G1/S transition of mitotic cell cycle |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0160049 |
negative regulation of cGAS/STING signaling pathway |
| Biological Process |
GO:0006470 |
protein dephosphorylation |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.