Search Results
Overview
| Uniprot ID | O00748 |
|---|---|
| Protein Name | Cocaine esterase |
| Gene Name | CES2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 297 | GCLRGKSKEEILAIN |
| 305 | EEILAINKPFKMIPG |
| 361 | MRIYDTQKEMDREAS |
| 454 | NIRPPHMKADHGDEL |
Function
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105). Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984)
Protein Sequence
10
MRLHRLRARL
20
SAVACGLLLL
30
LVRGQGQDSA
40
SPIRTTHTGQ
50
VLGSLVHVKG
60
ANAGVQTFLG
70
IPFAKPPLGP
80
LRFAPPEPPE
90
SWSGVRDGTT
100
HPAMCLQDLT
110
AVESEFLSQF
120
NMTFPSDSMS
130
EDCLYLSIYT
140
PAHSHEGSNL
150
PVMVWIHGGA
160
LVFGMASLYD
170
GSMLAALENV
180
VVVIIQYRLG
190
VLGFFSTGDK
200
HATGNWGYLD
210
QVAALRWVQQ
220
NIAHFGGNPD
230
RVTIFGESAG
240
GTSVSSLVVS
250
PISQGLFHGA
260
IMESGVALLP
270
GLIASSADVI
280
STVVANLSAC
290
DQVDSEALVG
300
CLRGKSKEEI
310
LAINKPFKMI
320
PGVVDGVFLP
330
RHPQELLASA
340
DFQPVPSIVG
350
VNNNEFGWLI
360
PKVMRIYDTQ
370
KEMDREASQA
380
ALQKMLTLLM
390
LPPTFGDLLR
400
EEYIGDNGDP
410
QTLQAQFQEM
420
MADSMFVIPA
430
LQVAHFQCSR
440
APVYFYEFQH
450
QPSWLKNIRP
460
PHMKADHGDE
470
LPFVFRSFFG
480
GNYIKFTEEE
490
EQLSRKMMKY
500
WANFARNGNP
510
NGEGLPHWPL
520
FDQEEQYLQL
530
NLQPAVGRAL
540
KAHRLQFWKK
550
ALPQKIQELE
EPEERHTEL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Molecular Function | GO:0106435 | carboxylesterase activity |
| Molecular Function | GO:0052689 | carboxylic ester hydrolase activity |
| Molecular Function | GO:0047374 | methylumbelliferyl-acetate deacetylase activity |
| Molecular Function | GO:0050253 | retinyl-palmitate esterase activity |
| Biological Process | GO:0050784 | cocaine catabolic process |
| Biological Process | GO:0098754 | detoxification |
| Biological Process | GO:0071273 | morphine catabolic process |
| Biological Process | GO:0006693 | prostaglandin metabolic process |
| Biological Process | GO:0006805 | xenobiotic metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.