Search Results
Overview
| Uniprot ID | O00757 |
|---|---|
| Protein Name | Fructose-1,6-bisphosphatase isozyme 2 |
| Gene Name | FBP2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 208 | VKIKKKGKIYSLNEG |
Function
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate
Protein Sequence
10
MTDRSPFETD
20
MLTLTRYVME
30
KGRQAKGTGE
40
LTQLLNSMLT
50
AIKAISSAVR
60
KAGLAHLYGI
70
AGSVNVTGDE
80
VKKLDVLSNS
90
LVINMVQSSY
100
STCVLVSEEN
110
KDAIITAKEK
120
RGKYVVCFDP
130
LDGSSNIDCL
140
ASIGTIFAIY
150
RKTSEDEPSE
160
KDALQCGRNI
170
VAAGYALYGS
180
ATLVALSTGQ
190
GVDLFMLDPA
200
LGEFVLVEKD
210
VKIKKKGKIY
220
SLNEGYAKYF
230
DAATTEYVQK
240
KKFPEDGSAP
250
YGARYVGSMV
260
ADVHRTLVYG
270
GIFLYPANQK
280
SPKGKLRLLY
290
ECNPVAYIIE
300
QAGGLATTGT
310
QPVLDVKPEA
320
IHQRVPLILG
330
SPEDVQEYLT
CVQKNQAGS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0070161 | anchoring junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0042132 | fructose 1,6-bisphosphate 1-phosphatase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006000 | fructose metabolic process |
| Biological Process | GO:0006094 | gluconeogenesis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.