Search Results
Overview
| Uniprot ID | O00762 |
|---|---|
| Protein Name | Ubiquitin-conjugating enzyme E2 C |
| Gene Name | UBE2C |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 18 | TSVAAARKGAEPSGG |
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit
Protein Sequence
10
MASQNRDPAA
20
TSVAAARKGA
30
EPSGGAARGP
40
VGKRLQQELM
50
TLMMSGDKGI
60
SAFPESDNLF
70
KWVGTIHGAA
80
GTVYEDLRYK
90
LSLEFPSGYP
100
YNAPTVKFLT
110
PCYHPNVDTQ
120
GNICLDILKE
130
KWSALYDVRT
140
ILLSIQSLLG
150
EPNIDSPLNT
160
HAAELWKNPT
170
AFKKYLQETY
SKQVTSQEP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005680 | anaphase-promoting complex |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0000151 | ubiquitin ligase complex |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0061631 | ubiquitin conjugating enzyme activity |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Molecular Function | GO:0044389 | ubiquitin-like protein ligase binding |
| Molecular Function | GO:0004842 | ubiquitin-protein transferase activity |
| Biological Process | GO:0031145 | anaphase-promoting complex-dependent catabolic process |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0010458 | exit from mitosis |
| Biological Process | GO:0010994 | free ubiquitin chain polymerization |
| Biological Process | GO:0031536 | positive regulation of exit from mitosis |
| Biological Process | GO:0045842 | positive regulation of mitotic metaphase/anaphase transition |
| Biological Process | GO:1904668 | positive regulation of ubiquitin protein ligase activity |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0070979 | protein K11-linked ubiquitination |
| Biological Process | GO:0070936 | protein K48-linked ubiquitination |
| Biological Process | GO:0000209 | protein polyubiquitination |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0030071 | regulation of mitotic metaphase/anaphase transition |
| Biological Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.