Search Results

Overview

Uniprot IDO00764
Protein NamePyridoxal kinase
Gene NamePDXK
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
119 CDPVLGDKWDGEGSM
161 AELLSGRKIHSQEEA

Function

Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (Probable) (PubMed:10987144, PubMed:17766369, PubMed:19351586, PubMed:31187503, PubMed:9099727). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions

Protein Sequence

10 MEEECRVLSI 20 QSHVIRGYVG 30 NRAATFPLQV 40 LGFEIDAVNS 50 VQFSNHTGYA 60 HWKGQVLNSD 70 ELQELYEGLR 80 LNNMNKYDYV 90 LTGYTRDKSF 100 LAMVVDIVQE 110 LKQQNPRLVY 120 VCDPVLGDKW 130 DGEGSMYVPE 140 DLLPVYKEKV 150 VPLADIITPN 160 QFEAELLSGR 170 KIHSQEEALR 180 VMDMLHSMGP 190 DTVVITSSDL 200 PSPQGSNYLI 210 VLGSQRRRNP 220 AGSVVMERIR 230 MDIRKVDAVF 240 VGTGDLFAAM 250 LLAWTHKHPN 260 NLKVACEKTV 270 STLHHVLQRT 280 IQCAKAQAGE 290 GVRPSPMQLE 300 LRMVQSKRDI 310 EDPEIVVQAT VL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0034774 secretory granule lumen
Cellular Component GO:0035580 specific granule lumen
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0031403 lithium ion binding
Molecular Function GO:0000287 magnesium ion binding
Molecular Function GO:0030955 potassium ion binding
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0008478 pyridoxal kinase activity
Molecular Function GO:0030170 pyridoxal phosphate binding
Molecular Function GO:0031402 sodium ion binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0009443 pyridoxal 5'-phosphate salvage

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.