Overview
| Uniprot ID | O00767 |
|---|
| Protein Name | Stearoyl-CoA desaturase |
|---|
| Gene Name | SCD |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 196 |
KHPAVKEKGSTLDLS |
| 341 |
YDRKKVSKAAILARI |
Function
Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity)
Protein Sequence
10
MPAHLLQDDI
20
SSSYTTTTTI
30
TAPPSRVLQN
40
GGDKLETMPL
50
YLEDDIRPDI
60
KDDIYDPTYK
70
DKEGPSPKVE
80
YVWRNIILMS
90
LLHLGALYGI
100
TLIPTCKFYT
110
WLWGVFYYFV
120
SALGITAGAH
130
RLWSHRSYKA
140
RLPLRLFLII
150
ANTMAFQNDV
160
YEWARDHRAH
170
HKFSETHADP
180
HNSRRGFFFS
190
HVGWLLVRKH
200
PAVKEKGSTL
210
DLSDLEAEKL
220
VMFQRRYYKP
230
GLLMMCFILP
240
TLVPWYFWGE
250
TFQNSVFVAT
260
FLRYAVVLNA
270
TWLVNSAAHL
280
FGYRPYDKNI
290
SPRENILVSL
300
GAVGEGFHNY
310
HHSFPYDYSA
320
SEYRWHINFT
330
TFFIDCMAAL
340
GLAYDRKKVS
350
KAAILARIKR
TGDGNYKSG
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Molecular Function |
GO:0005506 |
iron ion binding |
| Molecular Function |
GO:0016491 |
oxidoreductase activity |
| Molecular Function |
GO:0032896 |
palmitoyl-CoA 9-desaturase activity |
| Molecular Function |
GO:0004768 |
stearoyl-CoA 9-desaturase activity |
| Biological Process |
GO:1903966 |
monounsaturated fatty acid biosynthetic process |
| Biological Process |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
| Biological Process |
GO:0006636 |
unsaturated fatty acid biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.