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Overview

Uniprot IDO02668
Protein NameInter-alpha-trypsin inhibitor heavy chain H2
Gene NameITIH2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
477 DTASQLKKFYNQVST

Function

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes

Protein Sequence

10 MKGLTCFLLC 20 FLLSEAQGFE 30 IPTNGLSEFA 40 EYGDLAELAL 50 GKFHVVPGNR 60 RSQEGVDQVT 70 LYSYKVQSTI 80 TSRMANTVIQ 90 TKVVNHSPEP 100 QDVVFDIQIP 110 KGAFISNFSM 120 TVDGTKFTSS 130 IKEKTVGRAL 140 YWQARAKGKT 150 AGLVRSRALD 160 MENFKTEVNI 170 APGAKVQFEL 180 HYQEVKWRNL 190 GSYEHRIHLQ 200 PGRLAKHLEV 210 DVQIIEPQGL 220 RFLHVLDTFD 230 GHFDGVPVVV 240 KGQQKAHVAF 250 KPTVAQQRKC 260 PSCSETAVDG 270 ELVVMYDVNR 280 EQKAGELQLF 290 NGYFVHFFAP 300 ESMDPIPKNI 310 LFVIDVSGSM 320 WGIKMKQTVE 330 AMKTILDDLR 340 AEDQFSLVDF 350 NHNIRTWRND 360 LVSATKTQVA 370 DAKTYIEKIQ 380 PSGGTNINEA 390 LLRAIFILNE 400 ANNLGLLDPN 410 SVSLIILVSD 420 GDPTVGELQL 430 SKIQKNVKQN 440 IQDNVSLFSL 450 GIGFDVDYDF 460 LKRLSNDNRG 470 MAQRIYGNQD 480 TASQLKKFYN 490 QVSTPLLRNV 500 QFNYPQASVT 510 DVTQNSFPNY 520 FGGSEIVVAG 530 KFNPEKLEQL 540 QGIITATSAN 550 VELVLETLAE 560 MDGLEAFLAK 570 DRHADPDFTK 580 KLWAYLTINQ 590 LLDERSRAPS 600 AAVKKKITKS 610 ILQMSLDHHI 620 VTPLTAMVVE 630 NEAGDERMLA 640 DAPPQDQSCC 650 SGTLNYGRKV 660 TPNSLPSWVN 670 PLPTPRVPLP 680 AVGPSVIEAT 690 PPPHVMRVEN 700 DPHFIIYLPR 710 SQQNICFNID 720 SEPGKILNLV 730 SDPESGIVIN 740 GQLISAKKLK 750 DGKLSTYFGK 760 IGFYFQHEDV 770 KVEISTETIS 780 LSRGSRVSVL 790 SWSDSALVLN 800 QRVHISVKKE 810 KTVTVTLDQE 820 VSFSVLLHRV 830 WKKHPINVDF 840 LGIYIPPTTK 850 FSPKAHGLIG 860 QFMHEPEIRI 870 FNERPGKDPE 880 KPEASMEVKG 890 QTLVVTRGLQ 900 KDYRTDRVFG 910 TDVPCWFVHN 920 SGKGFIDGHY 930 KDYLVPLLYS FLKRP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005576 extracellular region
Molecular Function GO:0004867 serine-type endopeptidase inhibitor activity
Biological Process GO:0006953 acute-phase response
Biological Process GO:0030212 hyaluronan metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.