Search Results
Overview
| Uniprot ID | O08557 |
|---|---|
| Protein Name | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 |
| Gene Name | Ddah1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 199 | ESAQKALKIMQQMSD |
| 247 | EEYPESAKVYEKLKD |
| 253 | AKVYEKLKDHLLIPV |
Function
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation
Protein Sequence
10
MAGLSHPSVF
20
GRATHAVVRA
30
PPESLCRHAL
40
RRSQGEEVDF
50
ARAERQHQLY
60
VGVLGSKLGL
70
QVVQLPADES
80
LPDCVFVEDV
90
AVVCEETALI
100
TRPGAPSRRK
110
EVDMMKEALE
120
KLQLNIVEMK
130
DENATLDGGD
140
VLFTGREFFV
150
GLSKRTNQRG
160
AEILADTFKD
170
YAVSTVPVAD
180
SLHLKSFCSM
190
AGPNLIAIGS
200
SESAQKALKI
210
MQQMSDHRYD
220
KLTVPDDMAA
230
NCIYLNIPSK
240
GHVLLHRTPE
250
EYPESAKVYE
260
KLKDHLLIPV
270
SNSEMEKVDG
280
LLTCCSVFIN
KKTDS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0016597 | amino acid binding |
| Molecular Function | GO:0016403 | dimethylargininase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0030235 | nitric-oxide synthase regulator activity |
| Biological Process | GO:0006525 | arginine metabolic process |
| Biological Process | GO:0000052 | citrulline metabolic process |
| Biological Process | GO:0006527 | L-arginine catabolic process |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:1900038 | negative regulation of cellular response to hypoxia |
| Biological Process | GO:0043116 | negative regulation of vascular permeability |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:0045429 | positive regulation of nitric oxide biosynthetic process |
| Biological Process | GO:0003073 | regulation of systemic arterial blood pressure |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.