Search Results
Overview
| Uniprot ID | O08651 |
|---|---|
| Protein Name | D-3-phosphoglycerate dehydrogenase |
| Gene Name | Phgdh |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 21 | SLDPCCRKILQDGGL |
| 58 | LIVRSATKVTADVIN |
Function
Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Does not catalyze the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate
Protein Sequence
10
MAFANLRKIL
20
ISDSLDPCCR
30
KILQDGGLQV
40
VEKQNLSKEE
50
LIAELQDCEG
60
LIVRSATKVT
70
ADVINAAEKL
80
QVVGRAGTGV
90
DNVDLEAATR
100
KGVLVMNTPN
110
GNSLSAAELT
120
CGMLMCLARQ
130
IPQATASMKD
140
GKWDRKKFMG
150
TELNGKTLGI
160
LGLGRIGREV
170
AARMQAFGMK
180
TVGYDPIISP
190
EVAASFGVQQ
200
LPLEEIWPLC
210
DFITVHTPLL
220
PSTTGLLNDS
230
TFAQCKKGVR
240
VVNCARGGIV
250
DEGALLRALQ
260
SGQCAGAALD
270
VFTEEPPRDR
280
ALVDHENVIS
290
CPHLGASTKE
300
AQSRCGEEIA
310
VQFVDMVKGK
320
SLTGVVNAQA
330
LTSAFSPHTK
340
PWIGLAEALG
350
TLMHAWAGSP
360
KGTIQVVTQG
370
TSLKNAGTCL
380
SPAVIVGLLR
390
EASKQADVNL
400
VNAKLLVKEA
410
GLNVTTSHSP
420
GVPGEQGIGE
430
CLLTVALAGA
440
PYQAVGLVQG
450
TTPMLQMLNG
460
AVFRPEVPLR
470
RGQPLLLFRA
480
QPSDPVMLPT
490
MIGLLAEAGV
500
QLLSYQTSKV
510
SDGDTWHVMG
520
LSSLLPSLDA
530
WKQHVSEAFQ
FCF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0021915 | neural tube development |
| Biological Process | GO:0022008 | neurogenesis |
| Biological Process | GO:0031175 | neuron projection development |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0021510 | spinal cord development |
| Biological Process | GO:0019530 | taurine metabolic process |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0004617 | phosphoglycerate dehydrogenase activity |
| Biological Process | GO:0070314 | G1 to G0 transition |
| Biological Process | GO:0009448 | gamma-aminobutyric acid metabolic process |
| Biological Process | GO:0021782 | glial cell development |
| Biological Process | GO:0006541 | glutamine metabolic process |
| Biological Process | GO:0006544 | glycine metabolic process |
| Biological Process | GO:0006564 | L-serine biosynthetic process |
| Biological Process | GO:0006563 | L-serine metabolic process |
| Biological Process | GO:0006566 | L-threonine metabolic process |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.