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Overview

Uniprot IDO08749
Protein NameDihydrolipoyl dehydrogenase, mitochondrial
Gene NameDld
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
104 YYHMAHGKDFASRGI
122 EVRLNLEKMMEQKHS
127 LEKMMEQKHSAVKAL
132 EQKHSAVKALTGGIA
143 GGIAHLFKQNKVVHV
146 AHLFKQNKVVHVNGF
159 GFGKITGKNQVTATK
166 KNQVTATKADGSTQV
277 FKFKLNTKVTGATKK
410 GKSEEQLKEEGIEFK
430 FAANSRAKTNADTDG
440 ADTDGMVKILGHKST
445 MVKILGHKSTDRVLG
66 KSAQLGFKTVCIEKN

Function

Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (By similarity). In monomeric form may have additional moonlighting function as serine protease (PubMed:17404228). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity). The pyruvate dehydrogenase (PDH) complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). The E3 subunit catalyzes reoxidation of the dihydrolipoyl moiety on lipoyl-bearing domains (LBDs) of E2 with NAD+ as the ultimate electron acceptor (By similarity)

Protein Sequence

10 MQSWSRVYRS 20 LAKKGHFNRI 30 SHGLQGVSSV 40 PLRTYADQPI 50 EADVTVIGSG 60 PGGYVAAIKS 70 AQLGFKTVCI 80 EKNETLGGTC 90 LNVGCIPSKA 100 LLNNSHYYHM 110 AHGKDFASRG 120 IEIPEVRLNL 130 EKMMEQKHSA 140 VKALTGGIAH 150 LFKQNKVVHV 160 NGFGKITGKN 170 QVTATKADGS 180 TQVIDTKNIL 190 VATGSEVTPF 200 PGITIDEDTI 210 VSSTGALSLK 220 KVPEKLVVIG 230 AGVIGVELGS 240 VWQRLGADVT 250 AVEFLGHVGG 260 IGIDMEISKN 270 FQRILQRQGF 280 KFKLNTKVTG 290 ATKKSDGKID 300 VSVEAASGGK 310 AEVITCDVLL 320 VCIGRRPFTQ 330 NLGLEELGIE 340 LDPKGRIPVN 350 NRFQTKIPNI 360 YAIGDVVAGP 370 MLAHKAEDEG 380 IICVEGMAGG 390 AVHIDYNCVP 400 SVIYTHPEVA 410 WVGKSEEQLK 420 EEGIEFKIGK 430 FPFAANSRAK 440 TNADTDGMVK 450 ILGHKSTDRV 460 LGAHILGPGA 470 GEMVNEAALA 480 LEYGASCEDI 490 ARVCHAHPTL 500 SEAFREANLA AAFGKPINF

Gene Ontology

Classification GO ID Description
Biological Process GO:0007369 gastrulation
Cellular Component GO:0043159 acrosomal matrix
Cellular Component GO:0160157 branched-chain alpha-ketoacid dehydrogenase complex
Cellular Component GO:0005929 cilium
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0031514 motile cilium
Cellular Component GO:0043209 myelin sheath
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0160167 oxoadipate dehydrogenase complex
Cellular Component GO:0045252 oxoglutarate dehydrogenase complex
Cellular Component GO:0045254 pyruvate dehydrogenase complex
Molecular Function GO:0004148 dihydrolipoyl dehydrogenase (NADH) activity
Molecular Function GO:0050660 flavin adenine dinucleotide binding
Molecular Function GO:0043544 lipoamide binding
Molecular Function GO:0051287 NAD binding
Biological Process GO:0120551 2-oxoglutarate decarboxylation to succinyl-CoA
Biological Process GO:0006103 2-oxoglutarate metabolic process
Biological Process GO:0120552 branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA
Biological Process GO:0009083 branched-chain amino acid catabolic process
Biological Process GO:0051068 dihydrolipoamide metabolic process
Biological Process GO:0019474 L-lysine catabolic process to acetyl-CoA
Biological Process GO:0009106 lipoate metabolic process
Biological Process GO:0006120 mitochondrial electron transport, NADH to ubiquinone
Biological Process GO:0006508 proteolysis
Biological Process GO:0006086 pyruvate decarboxylation to acetyl-CoA
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0048240 sperm capacitation
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.