Overview
| Uniprot ID | O08773 |
|---|
| Protein Name | Regulator of G protein signaling 14 |
|---|
| Gene Name | Rgs14 |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 347 |
IKVYLVGKEQKALVL |
Function
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI) (PubMed:11976690). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerization and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division; required for completion of the first mitotic division of the embryo. Involved in visual memory processing capacity; when overexpressed in the V2 secondary visual cortex area. Involved in hippocampal-based learning and memory; acts as a suppressor of synaptic plasticity in CA2 neurons. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance
Protein Sequence
10
MPGKPKHLGV
20
PNGRMVLAVS
30
DGELTSTSGS
40
QAQGEGRGSS
50
LSIHSLPSGP
60
SSPFSTDEQP
70
VASWAQSFER
80
LLQDPRGLAY
90
FTEFLKKEFS
100
AENVTFWQAC
110
ERFQQIPASD
120
TKQLAQEAHN
130
IYHEFLSSQA
140
LSPVNIDRQA
150
WLSEEVLAQP
160
RPDMFRAQQL
170
QIFNLMKFDS
180
YARFVKSPLY
190
QECLLAEAEG
200
RPLREPGSSH
210
LGSPDTARKK
220
PKLKPGKSLP
230
LGVEELGQLP
240
LAEGRPLRKS
250
FRREMPGGAV
260
NSALRRESQG
270
SLNSSASLDL
280
GFLAFVSSKS
290
ESHRKSLGSG
300
EGESESRPGK
310
YCCVYLPDGT
320
ASLALARPGL
330
TIRDMLAGIC
340
EKRGLSLPDI
350
KVYLVGKEQK
360
ALVLDQDCTV
370
LADQEVRLEN
380
RITFQLELVG
390
LERVVRISAK
400
PTKRLQEALQ
410
PILAKHGLSL
420
DQVVLHRPGE
430
KQLVDLENLV
440
SSVASQTLVL
450
DTLPDAKTRE
460
ASSIPPCRSQ
470
GCLPRTQTKD
480
SHLPPLSSSL
490
SVEDASGSTG
500
KRQTCDIEGL
510
VELLNRVQSS
520
GAHDQRGLLR
530
KEDLVLPEFL
540
QLPSQRPGSQ
EAPP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0043197 |
dendritic spine |
| Cellular Component |
GO:0098978 |
glutamatergic synapse |
| Cellular Component |
GO:0005874 |
microtubule |
| Cellular Component |
GO:0016604 |
nuclear body |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0016605 |
PML body |
| Cellular Component |
GO:0014069 |
postsynaptic density |
| Cellular Component |
GO:0005819 |
spindle |
| Cellular Component |
GO:0000922 |
spindle pole |
| Molecular Function |
GO:0001965 |
G-protein alpha-subunit binding |
| Molecular Function |
GO:0005092 |
GDP-dissociation inhibitor activity |
| Molecular Function |
GO:0032794 |
GTPase activating protein binding |
| Molecular Function |
GO:0005096 |
GTPase activator activity |
| Molecular Function |
GO:0008017 |
microtubule binding |
| Molecular Function |
GO:0019901 |
protein kinase binding |
| Molecular Function |
GO:0030159 |
signaling receptor complex adaptor activity |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0007059 |
chromosome segregation |
| Biological Process |
GO:0007612 |
learning |
| Biological Process |
GO:0007616 |
long-term memory |
| Biological Process |
GO:0060291 |
long-term synaptic potentiation |
| Biological Process |
GO:0000278 |
mitotic cell cycle |
| Biological Process |
GO:0050804 |
modulation of chemical synaptic transmission |
| Biological Process |
GO:0070373 |
negative regulation of ERK1 and ERK2 cascade |
| Biological Process |
GO:0045744 |
negative regulation of G protein-coupled receptor signaling pathway |
| Biological Process |
GO:0043407 |
negative regulation of MAP kinase activity |
| Biological Process |
GO:0031914 |
negative regulation of synaptic plasticity |
| Biological Process |
GO:0006913 |
nucleocytoplasmic transport |
| Biological Process |
GO:0048008 |
platelet-derived growth factor receptor signaling pathway |
| Biological Process |
GO:0043547 |
positive regulation of GTPase activity |
| Biological Process |
GO:0050769 |
positive regulation of neurogenesis |
| Biological Process |
GO:0008277 |
regulation of G protein-coupled receptor signaling pathway |
| Biological Process |
GO:0006979 |
response to oxidative stress |
| Biological Process |
GO:0007051 |
spindle organization |
| Biological Process |
GO:0008542 |
visual learning |
| Biological Process |
GO:0010070 |
zygote asymmetric cell division |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.